教师基本信息

姓名：张文宏

职称：教授

职务：结核课题组组长

电子邮箱：[email protected]

办公地点：生科院C507

研究方向

感染性疾病病原学机制；结核队疫苗；新发突发传染病的病原学和发生发展机制。

个人简介

张文宏，教授，博士生导师，全国政协委员

复旦大学附属华山医院感染科主任、广州实验室（上海基地）主任、国家感染病临床中心主任、复旦大学临床医学院内科学系主任、复旦大学生命科学学院结核课题组组长。为教育部长江学者特聘教授，全国抗击新冠肺炎疫情先进个人，全国优秀共产党员。

入选教育部新世纪优秀人才、上海市领军人才、上海市优秀学科带头人。获全国创新争先奖，上海市劳动模范，国之名医·优秀风范，上海市医务工匠，上海市银蛇奖。兼中国医师协会内科医师分会副主委，中华预防医学会感染预防与控制分会副主委，中华医学会感染病学分会副主任委员兼秘书长，上海市抗击新冠临床救治专家组长，抗击新冠公共卫生专家组共同组长。兼《中华传染病杂志》总编辑，《微生物与感染》主编，《Emerging Microbes and Infections》副主编，《international Journal of Tuberculosis and Lung Diseases》（国际防痨联盟会刊）副主编。

长期从事感染性疾病的发病机制与诊疗研究，牵头了国家十五攻关到十二五攻关以来的多项传染病重大专项课题。（1）建立了以精准诊断为核心的精准病原诊断研究平台，显著提高了不明原因发热等疑难感染病以及新发突发传染病的病因诊断能力，在国际上首次发现并论证了猪疱疹病毒跨界从猪到人的传播，在国际上首次用二代测序技术快速确诊了输入性非洲锥虫病，72小时建立与WHO通道并拿到WHO捐助药物，建立了新发传染病医院早期预警和输入性传染病快速反应的模版，为提升我国的新发和再发传染病反应体系的效率提供参考。这些成果也对于解决一带一路相关的输入性感染病的精准诊治提供了技术支撑。（2）在结核病研究方面居于国内领先，自主研发的中国自主产权的结核病免疫诊断试剂盒已经进入SFDA评审阶段。牵头了我国在国际上第一个潜伏结核干预国际注册多中心临床研究；在建立MDR-TB分子药敏和表型药敏的检测平台的基础上，牵头开展多中心多重耐药结核病治疗新方案的临床研究，参与医院覆盖全国22个省市自治区，建立耐药结核病和重症结核病的个体化治疗策略，发表相关成果被连续多版WHO指南引用，作为中国唯一本土推荐方案纳入国内专家共识。现牵头国家多中心项目3项：十三五国家科技重大专项“耐药结核病治疗新方案和新技术的研究及评估”、“TRUST-TB研究（中国耐多药结核病超短程口服治疗）”、“GRACE-TB研究（全基因组测序指导下耐多药结核病治疗）”。（3）此次新冠疫情期间，他和团队通过科学防控的精神对控制疫情做出贡献，制定了上海新冠肺炎诊治专家共识，防控与救治取得了系列的成果。以第一作者/通讯作者在国内外期刊上发表论文300余篇，包括SCI论文100余篇。其研究成果获国家授权专利9项，并获中华医学奖、上海市科技进步奖等多项科技成果奖。主编及参编各类感染病学专著20部。

受教育经历（从大学本科开始，按时间降序排列）

2003/07 – 2004/07，美国哈佛大学医学院Beth Israel Deaconess医学中心，博士后

1997/07 – 2001/01，复旦大学，传染病学，博士

1993/09 – 1996/07，上海医科大学研究生院，中西医结合专业，硕士

1987/09 – 1993/07，上海医科大学医学系，本科

研究工作经历（按时间降序排列）

2018/08 – 至今，复旦大学，生命科学学院，教授，结核课题组PI，从事结核病新疫苗开发及相关保护机制

2012/10 – 至今，复旦大学，卫生部重点分子病毒实验室，教授，PI，从事感染性疾病发病机制的研究

2008/05 – 至今，复旦大学，附属华山医院感染科，教授，从事感染性疾病的临床诊治和发病机制的研究

2007/03-2008/04，复旦大学，附属华山医院感染科，主任医师，从事感染性疾病的临床诊治和发病机制的研究，结核病的免疫发病机制和耐药结核病的快速诊断

2003/07 – 2004/08，哈佛大学医学院，Beth Israel Deaconess医学中心，从事结核病免疫发病机制研究

2002/12 – 2007/03，复旦大学，附属华山医院感染科，副主任医师，从事感染性疾病的临床诊治，结核病的免疫发病机制和耐药结核病的快速诊断

2001/04 – 2001/10，香港大学，微生物学系，访问学者，从事结核病的分子诊断技术研究

1998/05 – 2002/11，复旦大学，附属华山医院感染科，主治医师，从事感染性疾病的临床诊治、分子诊断和耐药机制研究

1993/09 – 1998/04，复旦大学，附属华山医院感染科，医师，从事感染性疾病的临床诊治

科研项目（近5年）

落地生科院包括国家重大专项、传染病国家实验室上海基地培育等纵向和联合实验室横向科研项目共计14项。

招生专业

微生物学

代表性论文和论著

 1.Ai, J., J. Guo, H. Zhang, Y. Zhang, H. Yang, K. Lin, J. Song, Z. Fu, M. Fan, Q. Zhang, H. Wang, Y. Zhao, Z. He, A. Cui, Y. Zhou, J. Wu, M. Zhou, G. Yuan, B. Kang, N. Zhao, Y. Xu, M. Zhu, Y. Wang, Z. Zhang, N. Jiang, C. Qiu, C. Xu and W. Zhang (2022). "Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling." Cell Discov 8(1): 114.

 2.Fu, Z. F., H. C. Zhang, Y. Zhang, P. Cui, Y. Zhou, H. Y. Wang, K. Lin, X. Zhou, J. Wu, H. L. Wu, W. H. Zhang and J. W. Ai (2021). "Evaluations of Clinical Utilization of Metagenomic Next-Generation Sequencing in Adults With Fever of Unknown Origin." Front Cell Infect Microbiol 11: 745156.

 3.Wang, X., W. Li, W. Wang, S. Wang, T. Xu, J. Chen and W. Zhang (2021). "Involvement of Small Colony Variant-Related Heme Biosynthesis Genes in Staphylococcus aureus Persister Formation in vitro." Front Microbiol 12: 756809.

 4.Zhang, W., T. Yang, H. Zhang, Y. Xu, Q. Yang, Q. Liu, Y. Gao, J. Wu, L. Shao and W. Zhang (2021). "Biomarker screening and validation for the differentiation of bloodstream infection from adult-onset Still's disease: A prospective cohort study." Cytokine 146: 155642.

 5.Ai, J., X. Wang, X. He, X. Zhao, Y. Zhang, Y. Jiang, M. Li, Y. Cui, Y. Chen, R. Qiao, L. Li, L. Yang, Y. Li, Z. Hu, W. Zhang and P. Wang (2022). "Antibody evasion of SARS-CoV-2 Omicron BA.1, BA.1.1, BA.2, and BA.3 sub-lineages." Cell Host Microbe 30(8): 1077-1083.e1074.

 6.Ai, J., H. Zhang, Q. Zhang, Y. Zhang, K. Lin, Z. Fu, J. Song, Y. Zhao, M. Fan, H. Wang, C. Qiu, Y. Zhou and W. Zhang (2022). "Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and Variants of Concern." Cell Res 32(1): 103-106.

 7.Ai, J., H. Zhang, Y. Zhang, K. Lin, Y. Zhang, J. Wu, Y. Wan, Y. Huang, J. Song, Z. Fu, H. Wang, J. Guo, N. Jiang, M. Fan, Y. Zhou, Y. Zhao, Q. Zhang, Q. Liu, J. Lv, P. Li, C. Qiu and W. Zhang (2022). "Omicron variant showed lower neutralizing sensitivity than other SARS-CoV-2 variants to immune sera elicited by vaccines after boost." Emerg Microbes Infect 11(1): 337-343.

 8.Ai, J., Y. Zhang, H. Zhang, Q. Zhang, Z. Fu, K. Lin, J. Song, Y. Zhao, M. Fan, H. Wang, Y. Zhou, X. Chen, C. Qiu and W. Zhang (2022). "Safety and immunogenicity of a third-dose homologous BBIBP-CorV boosting vaccination: interim results from a prospective open-label study." Emerg Microbes Infect 11(1): 639-647.

 9.Jia, L., S. Weng, J. Wu, X. Tian, Y. Zhang, X. Wang, J. Wang, D. Yan, W. Wang, F. Fang, Z. Zhu, C. Qiu, W. Zhang, Y. Xu and Y. Wan (2022). "Preexisting antibodies targeting SARS-CoV-2 S2 cross-react with commensal gut bacteria and impact COVID-19 vaccine induced immunity." Gut Microbes 14(1): 2117503.

 10.Jia, L., Y. Zhou, S. Li, Y. Zhang, D. Yan, W. Wang, W. Zhang, Y. Wan and C. Qiu (2022). "Omicron Booster in Ancestral Strain Vaccinated Mice Augments Protective Immunities Against Both Delta and Omicron Variants." Front Immunol 13: 897879.

 11.Lin, K., Y. Zhou, J. Ai, Y. A. Wang, S. Zhang, C. Qiu, C. Lian, B. Gao, T. Liu, H. Wang, H. Zhang, Y. Zhang, Z. Fu, D. Li, N. Jiang, J. Guo, J. Wu, Y. O. Wang, S. Song, Q. Li, Y. Yin, J. Xia, Y. Xu, L. S. Yeap, X. Zheng, Y. Gu, H. Liu, W. Zhang and F. L. Meng (2022). "B cell receptor signatures associated with strong and poor SARS-CoV-2 vaccine responses." Emerg Microbes Infect 11(1): 452-464.

 12.Lin, S., W. Hua, S. Wang, Y. Zhang, X. Chen, H. Liu, L. Shao, J. Chen and W. Zhang (2022). "In vitro assessment of 17 antimicrobial agents against clinical Mycobacterium avium complex isolates." BMC Microbiol 22(1): 175.

 13.Lin, S., W. Zhang, Y. Xu, Q. Liu, W. Zhang and L. Shao (2022). "Gene expression analysis reveals immune and metabolic candidate pathways in the pathogenesis of chronic otitis media." Am J Transl Res 14(1): 264-274.

 14.Liu, Q., Y. Gao, T. Yang, Z. Zhou, K. Lin, W. Zhang, T. Li, Y. Lu, L. Shao and W. Zhang (2022). "nCD64 index as a novel inflammatory indicator for the early prediction of prognosis in infectious and non-infectious inflammatory diseases: An observational study of febrile patients." Front Immunol 13: 905060.

 15.Ruan, Q. L., Q. L. Yang, F. Sun, W. Liu, Y. J. Shen, J. Wu, N. Jiang, J. Y. Zhou, L. Y. Shao and W. H. Zhang (2022). "Recurrent pulmonary tuberculosis after treatment success: a population-based retrospective study in China." Clin Microbiol Infect 28(5): 684-689.

 16.Xu, Y., Q. Yang, J. Zhou, F. Zhou, Y. Hezhang, Y. Gao, L. Shao, J. Shi, Q. Ruan and W. Zhang (2022). "Comparison of QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold-Plus in the Diagnosis of Mycobacterium tuberculosis Infections in Immunocompromised Patients: a Real-World Study." Microbiol Spectr 10(2): e0187021.

 17.Zhang, H., W. Hua, S. Lin, Y. Zhang, X. Chen, S. Wang, J. Chen and W. Zhang (2022). "In vitro Susceptibility of Nontuberculous Mycobacteria to Tedizolid." Infect Drug Resist 15: 4845-4852.

 18.Zhang, Y., J. Ai, J. Bao and W. Zhang (2022). "Lessons learned from the COVID-19 control strategy of the XXXII Tokyo Summer Olympics and the XXIV Beijing Winter Olympics." Emerg Microbes Infect 11(1): 1711-1716.

 19.Zhang, Y., C. Chen, J. Wu, J. Jin, T. Xu, Y. Zhou, P. Cui, J. Chen, S. Chen, N. Jiang and W. Zhang (2022). "Sequence-Based Genomic Analysis Reveals Transmission of Antibiotic Resistance and Virulence among Carbapenemase-Producing Klebsiella pneumoniae Strains." mSphere 7(3): e0014322.

 20.Zhang, Y., N. Jiang, W. Qi, T. Li, Y. Zhang, J. Wu, H. Zhang, M. Zhou, P. Cui, T. Yu, Z. Fu, Y. Zhou, K. Lin, H. Wang, T. Wei, Z. Zhu, J. Ai, C. Qiu and W. Zhang (2022). "SARS-CoV-2 intra-host single-nucleotide variants associated with disease severity." Virus Evol 8(2): veac106.

 21.Zhang, Y., N. Jiang, W. Qi, T. Li, Y. Zhang, H. Zhang, J. Wu, Z. Zhu, J. Ai, C. Qiu and W. Zhang (2022). "Intra-host SARS-CoV-2 single-nucleotide variants emerged during the early stage of COVID-19 pandemic forecast population fixing mutations." J Infect 84(5): 722-746.

 22.Zhang, Y., S. Yu, C. Chen, F. Sun, L. Zhou, H. Yao, J. Hu, S. Li, J. Ai, N. Jiang, J. Wang, Q. Liu, J. Jin and W. Zhang (2022). "Comprehensive Surveillance and Sampling Reveal Carbapenem-Resistant Organism Spreading in Tertiary Hospitals in China." Infect Drug Resist 15: 4563-4573.

 23.Zhang, Y., Q. Yue, H. Zhu, J. Song, D. Li, W. Liu, S. Jiang, N. Jiang, C. Qiu, J. Ai, Y. Zhang and W. Zhang (2022). "Serum Metabolic Correlates of the Antibody Response in Subjects Receiving the Inactivated COVID-19 Vaccine." Vaccines (Basel) 10(11).

 24.Zhang, Y., H. Zhang and W. Zhang (2022). "SARS-CoV-2 variants, immune escape, and countermeasures." Front Med 16(2): 196-207.

 25.Cai, J., K. Lin, H. Zhang, Q. Xue, K. Zhu, G. Yuan, Y. Sun, F. Zhu, J. Ai, S. Wang and W. Zhang (2023). "A one-year follow-up study of systematic impact of long COVID symptoms among patients post SARS-CoV-2 omicron variants infection in Shanghai, China." Emerg Microbes Infect 12(2): 2220578.

 26.Chen, X., R. Li, S. Ge, Y. Li, C. Cai, T. Weng, Y. Zhang, J. Jiang, Z. Feng, Y. Chen, Y. Zhang, J. Ma, D. H. Persing, J. Chen, Y. W. Tang, F. Sun and W. Zhang (2023). "Rapid Detection of Extensive Drug Resistance by Xpert MTB/XDR Optimizes Therapeutic Decision-Making in Rifampin-Resistant Tuberculosis Patients." J Clin Microbiol 61(6): e0183222.

 27.Li, R., Y. Li, X. Chen, L. Jia, H. Yu, Y. Huang, Q. Wu, M. Xiao, S. Ge, Y. Zhang, Z. Feng, Q. Li, Y. Xu, W. Shi, F. Sun and W. Zhang (2023). "Ability of the MeltPro MTB/PZA Assay to Detect Susceptibility to Pyrazinamide in Rifampin-Resistant Tuberculosis Patients." Microbiol Spectr 11(3): e0483622.

 28.Lin, K., H. C. Zhang, Y. Zhang, Y. Zhou, Z. F. Fu, H. Y. Wang, Y. H. Zhao, C. Qiu, M. X. Fan, J. Y. Song, J. W. Ai and W. H. Zhang (2023). "Clinical application and drug-use-guidance value of metagenomic next-generation sequencing in central nervous system infection." Am J Transl Res 15(1): 47-62.

 29.Lin, K., Y. Zhao, B. Xu, S. Yu, Z. Fu, Y. Zhang, H. Wang, J. Song, M. Fan, Y. Zhou, J. Ai, C. Qiu, H. Zhang and W. Zhang (2023). "Clinical Diagnostic Performance of Droplet Digital PCR for Suspected Bloodstream Infections." Microbiol Spectr 11(1): e0137822.

 30.Ruan, Q. L., Z. C. Wang, C. J. Wei, W. Wang, Q. L. Yang, J. Wu, Y. M. Wan, L. L. Ge, W. H. Zhang and Q. F. Li (2023). "Neutralizing antibodies against SARS-CoV-2 virus after vaccination in patients with neurofibromatosis type 1." Signal Transduct Target Ther 8(1): 233.

 31.Wu, Q., H. Wang, J. Cai, J. Ai, Y. Li, H. Zhang, S. Wang, F. Sun, Y. Wu, J. Zhou, Y. Wang, H. Yu and W. Zhang (2023). "Vaccination effects on post-infection outcomes in the Omicron BA.2 outbreak in Shanghai." Emerg Microbes Infect 12(1): e2169197.

 32.Zhang, H., M. Zhang, Q. Zhang, Y. Yu, F. Zhang, J. Wang, M. Zhou, T. Yu, C. Shen, S. Yu, Y. Huang, Y. Huang, J. Zhang, J. Jin, C. Qiu, L. Guojun and W. Zhang (2023). "Visualizing in situ viral replication across the natural history of chronic HBV infection." Hepatol Commun 7(4).