这要看你是用 so…as 表示什么意思，用于什么结构。如果是用 so…as 在疑问句中表示“跟……一样”，那不可以；但如果是用于其他结构则是有可能的，比如用于so…as to do sth。如：

Would you be so kind as to tell me the time? 你能告诉我现在的时间吗？

Would you be so kind as to keep me informed? 请随时告诉我一些情况，好吗？

How could she have been so foolish as to fall in love with him? 她怎么这么傻，竟然爱上他？

How can you be so cruel as to criticize her weight? 拿她的体重打趣，你怎么能如此伤人呢？