The ST-LINK/V2 is an in-circuit debugger and programmer for the STM8 and STM32 microcontrollers. The single-wire interface module (SWIM) and JTAG/serial wire debugging (SWD) interfaces are used to communicate with any STM8 or STM32 microcontroller located on an application board. In addition to providing the same functionalities as the ST-LINK/V2, the ST-LINK/V2-ISOL features digital isolation between the PC and the target application board. It also withstands voltages of up to 1000 Vrms.

STM8 applications use the USB full-speed interface to communicate with the ST Visual Develop (STVD-STM8) or ST Visual Programmer (STVP-STM8) software, or with integrated development environments from third-parties.

STM32 applications use the USB full-speed interface to communicate with the STM32CubeIDE software tool or with integrated development environments from third-parties.