以色列魏兹曼科学研究所Steffen Jung团队近期取得重要工作进展，他们研究提出，经典单核细胞的个体发育决定其作为组织巨噬细胞的功能和命运。相关研究成果2024年5月14日在线发表于《免疫》杂志上。

据介绍，经典单核细胞（CM）是在血液中循环的短暂性骨髓免疫细胞。新的证据表明，CM可以有不同的个体发生，起源于粒细胞-单核细胞或单核细胞-树突状细胞祖细胞（GMP或MDP）。

研究人员报道了能够分离小鼠GMP和MDP来源的CM的表面标记物，即GMP-Mo和MDP-Mo，以及它们的功能表征，包括过继细胞转移后的命运定义。GMP-Mo和MDP-Mo产生的同源CM后代（如驻血非典型单核细胞和肠道巨噬细胞）的增加量相同；然而，这些细胞在硬脑膜和肺部等其他各种选定组织中的播种情况各不相同。具体而言，GMP-Mo和MDP-Mo分化为不同的间质肺巨噬细胞，将CM二分法与先前报道的肺巨噬细胞异质性联系起来。

总之，这一研究表明，小鼠体内存在两种功能截然不同的 CM 亚群，它们对外周组织巨噬细胞群在体内平衡和受到挑战时的贡献各不相同。

附：英文原文

Title: Classical monocyte ontogeny dictates their functions and fates as tissue macrophages

Author: Sébastien Trzebanski, Jung-Seok Kim, Niss Larossi, Ayala Raanan, Daliya Kancheva, Jonathan Bastos, Montaser Haddad, Aryeh Solomon, Ehud Sivan, Dan Aizik, Jarmila Sekeresova Kralova, Mor Gross-Vered, Sigalit Boura-Halfon, Tsvee Lapidot, Ronen Alon, Kiavash Movahedi, Steffen Jung

Issue&Volume: 2024-05-14

Abstract: Classical monocytes (CMs) are ephemeral myeloid immune cells that circulate in theblood. Emerging evidence suggests that CMs can have distinct ontogeny and originatefrom either granulocyte-monocyte- or monocyte-dendritic-cell progenitors (GMPs orMDPs). Here, we report surface markers that allowed segregation of murine GMP- andMDP-derived CMs, i.e., GMP-Mo and MDP-Mo, as well as their functional characterization,including fate definition following adoptive cell transfer. GMP-Mo and MDP-Mo yieldedan equal increase in homeostatic CM progeny, such as blood-resident non-classicalmonocytes and gut macrophages; however, these cells differentially seeded variousother selected tissues, including the dura mater and lung. Specifically, GMP-Mo andMDP-Mo differentiated into distinct interstitial lung macrophages, linking CM dichotomyto previously reported pulmonary macrophage heterogeneity. Collectively, we provideevidence for the existence of two functionally distinct CM subsets in the mouse thatdifferentially contribute to peripheral tissue macrophage populations in homeostasisand following challenge.

DOI: 10.1016/j.immuni.2024.04.019

Source: https://www.cell.com/immunity/abstract/S1074-7613(24)00224-3

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