GDNF induces mechanical hyperalgesia in muscle by reducing I(BK) in isolectin B4 |
您所在的位置:网站首页 › muscle action › GDNF induces mechanical hyperalgesia in muscle by reducing I(BK) in isolectin B4 |
We have assessed the mechanism underlying glial cell-derived neurotrophic factor (GDNF)-induced mechanical hyperalgesia in the gastrocnemius muscle, using patch clamp electrophysiology, in vivo electrophysiology and behavioral studies. Cultured isolectin B4-positive (IB4+) dorsal root ganglion neurons that innervated this muscle were held under current clamp; the majority developed an increase in action potential duration (a factor of increase of 2.29±0.24, compared to 1.13±0.17 in control, P |
CopyRight 2018-2019 办公设备维修网 版权所有 豫ICP备15022753号-3 |