NONMEN输出结果

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NONMEN输出结果

2024-07-15 06:36| 来源: 网络整理| 查看: 265

NONMEN输出结果 NONMEN输出结果控制文件和软件授权信息 NM-TRAN PREDPP 估算方法中间运算结果最终模型的参数估算值终模型的参数估算值附加文件

NONMEN输出结果

最重要的输出文件lst文件

1iv infusion 3cp\infusion_3cp.nm7\infusion_3cp.lst

简介输出文件

1iv infusion 3cp\infusion_3cp.nm7\infusion_3cp.smr 控制文件和软件授权信息

lst文件内

完整运行的控制文件授权信息 1234License Registered to: XXXX ;购买软件许可的机构 Expiration Date: XXXX ;到期时间 Current Date: XXXX ;当前日期 Days until program expires : XXX ;软件授权剩余天数 NM-TRAN 12345 NO. OF DATA RECS IN DATA SET: 475 数据行数 NO. OF DATA ITEMS IN DATA SET: 17 数据变量数 ID DATA ITEM IS DATA ITEM NO.: 2 ID所在列 DEP VARIABLE IS DATA ITEM NO.: 6 观测值所在列 MDV DATA ITEM IS DATA ITEM NO.: 9 MDV所在列

PREDPP

房室相关信息

123456 COMPT. NO. FUNCTION INITIAL ON/OFF DOSE DEFAULT DEFAULT STATUS ALLOWED ALLOWED FOR DOSE FOR OBS. 1 CENTRAL ON NO YES YES YES 2 PERIPH1 ON NO YES NO NO 3 PERIPH2 ON NO YES NO NO 4 OUTPUT OFF YES NO NO NO

给药信息

1234 EVENT ID DATA ITEM IS DATA ITEM NO.: 17 TIME DATA ITEM IS DATA ITEM NO.: 3 DOSE AMOUNT DATA ITEM IS DATA ITEM NO.: 7 DOSE RATE DATA ITEM IS DATA ITEM NO.: 8 估算方法

估算方法

123456789ANALYSIS TYPE: POPULATION NUMBER OF SADDLE POINT RESET ITERATIONS: 0 GRADIENT METHOD USED: NOSLOW CONDITIONAL ESTIMATES USED: YES CENTERED ETA: NO EPS-ETA INTERACTION: YES LAPLACIAN OBJ. FUNC.: NO NO. OF FUNCT. EVALS. ALLOWED: 9999 NO. OF SIG. FIGURES REQUIRED: 3 中间运算结果 1**ITERATION NO.: 0 (迭代次数 )** 1**OBJECTIVE VALUE: 2303.85369963211 （目标函数值）** 1**NO. OF FUNC. EVALS.: 10 （函数估算次数）** 1 **CUMULATIVE NO. OF FUNC. EVALS.: 10（累计估算次数）**

参数估算值

1234NPARAMETR: 5.0558E+01 1.0513E+01 1.5310E+01 4.1132E+01 1.9719E+01 2.0763E+01 1.9992E-02 1.9970E-02 2.0115E-02 2.0149E-02 2.0703E-02 9.5814E-02 PARAMETER: 5.8496E-02 1.4998E-01 1.2045E-01 1.2790E-01 8.5875E-02 1.3745E-01 9.9789E-02 9.9257E-02 1.0287E-01 1.0371E-01 1.1728E-01 7.8620E-02

梯度

12GRADIENT: 1.0307E+02 -1.2413E+02 -5.0791E+01 -6.9290E+01 3.5080E+01 -9.3004E+01 5.2462E-01 1.8444E+00 -7.1247E+00 -9.2107E+00 -4.2924E+01 5.3097E+01

结果示例：

12345678910111213141516171819202122232425262728293031323334350ITERATION NO.: 0 (迭代次数 ) OBJECTIVE VALUE: 2303.85369963211 NO. OF FUNC. EVALS.: 10 CUMULATIVE NO. OF FUNC. EVALS.: 10 NPARAMETR: 5.2700E+01 1.0000E+01 1.5000E+01 4.0000E+01 2.0000E+01 2.0000E+01 2.0000E-02 2.0000E-02 2.0000E-02 2.0000E-02 2.0000E-02 1.0000E-01 PARAMETER: 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 GRADIENT: 1.0307E+02 -1.2413E+02 -5.0791E+01 -6.9290E+01 3.5080E+01 -9.3004E+01 5.2462E-01 1.8444E+00 -7.1247E+00 -9.2107E+00 -4.2924E+01 5.3097E+01 0ITERATION NO.: 1 OBJECTIVE VALUE: 2294.06567680895 NO. OF FUNC. EVALS.: 12 CUMULATIVE NO. OF FUNC. EVALS.: 22 NPARAMETR: 5.0558E+01 1.0513E+01 1.5310E+01 4.1132E+01 1.9719E+01 2.0763E+01 1.9992E-02 1.9970E-02 2.0115E-02 2.0149E-02 2.0703E-02 9.5814E-02 PARAMETER: 5.8496E-02 1.4998E-01 1.2045E-01 1.2790E-01 8.5875E-02 1.3745E-01 9.9789E-02 9.9257E-02 1.0287E-01 1.0371E-01 1.1728E-01 7.8620E-02 GRADIENT: -4.3681E+01 -2.1561E+00 -2.0097E+01 -1.3147E+01 -1.5383E+01 -6.9617E+00 2.9926E+00 6.2304E+00 -5.3722E+00 -9.2730E+00 -2.0838E+01 5.0299E+01 0ITERATION NO.: 2 OBJECTIVE VALUE: 2290.80399734753 NO. OF FUNC. EVALS.: 12 CUMULATIVE NO. OF FUNC. EVALS.: 34 NPARAMETR: 5.2420E+01 1.0669E+01 1.5721E+01 4.2003E+01 1.9975E+01 2.1114E+01 1.9862E-02 1.9700E-02 2.0376E-02 2.0589E-02 2.1831E-02 8.5164E-02 PARAMETER: 9.4666E-02 1.6475E-01 1.4696E-01 1.4887E-01 9.8735E-02 1.5421E-01 9.6548E-02 9.2436E-02 1.0931E-01 1.1451E-01 1.4379E-01 1.9707E-02 GRADIENT: 5.9994E+01 3.8143E+01 -3.2317E-01 4.7986E+00 -8.0643E+00 1.3449E+01 2.6998E+00 5.7923E+00 -4.8725E+00 -9.2573E+00 -3.1531E+00 4.2503E+01 0ITERATION NO.: 3 OBJECTIVE VALUE: 2286.96069628843 NO. OF FUNC. EVALS.: 11 CUMULATIVE NO. OF FUNC. EVALS.: 45 NPARAMETR: 5.1687E+01 1.0348E+01 1.6216E+01 4.2732E+01 2.0526E+01 2.1135E+01 1.9585E-02 1.9121E-02 2.0916E-02 2.1572E-02 2.3392E-02 6.7229E-02 PARAMETER: 8.0596E-02 1.3423E-01 1.7792E-01 1.6608E-01 1.2596E-01 1.5519E-01 8.9506E-02 7.7534E-02 1.2240E-01 1.3783E-01 1.7832E-01 -9.8533E-02 GRADIENT: -2.4643E+00 -3.0654E+00 3.5601E+01 -1.4332E+01 5.5020E+01 -7.8835E+00 3.6861E+00 6.3920E+00 -4.3786E+00 -9.5467E+00 2.6582E+01 2.6217E+01 最终模型的参数估算值 123MINIMIZATION SUCCESSFUL 最小化成功 NO. OF FUNCTION EVALUATIONS USED: 317 函数估算次数 NO. OF SIG. DIGITS IN FINAL EST.: 3.4 函数估算有效位数

ETA统计：算术平均值，方差，统计个数，se的p值（与0比较）

1234 ETABAR: -5.4972E-04 1.6467E-04 -5.9433E-03 0.0000E+00 5.9833E-03 0.0000E+00 SE: 2.1583E-02 1.0976E-02 1.7510E-02 0.0000E+00 2.6573E-02 0.0000E+00 N: 36 36 36 36 36 36 P VAL.: 9.7968E-01 9.8803E-01 7.3430E-01 1.0000E+00 8.2185E-01 1.0000E+00

ETA与EPS的收缩

123456 ETASHRINKSD(%) 4.1022E+00 3.8623E+01 3.4669E+01 1.0000E+02 2.0960E+01 1.0000E+02 ETASHRINKVR(%) 8.0361E+00 6.2329E+01 5.7319E+01 1.0000E+02 3.7527E+01 1.0000E+02 EBVSHRINKSD(%) 5.3013E+00 3.9514E+01 3.5728E+01 0.0000E+00 2.1549E+01 0.0000E+00 EBVSHRINKVR(%) 1.0321E+01 6.3414E+01 5.8691E+01 0.0000E+00 3.8455E+01 0.0000E+00 EPSSHRINKSD(%) 9.5466E+00 9.5466E+00 EPSSHRINKVR(%) 1.8182E+01 1.8182E+01 1 TOTAL DATA POINTS NORMALLY DISTRIBUTED (N): 439 总体观测事件个数 1TOTAL DATA POINTS NORMALLY DISTRIBUTED (N): 439 个体间变异ETA值的个数

剩余时间

123 Elapsed estimation time in seconds: 6.27 Elapsed covariance time in seconds: 9.47 Elapsed postprocess time in seconds: 0.07 终模型的参数估算值

最小目标函数值（ #OBJV:）

1234567 ************************************************************************************************************************ ******************** ******************** ******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ******************** #OBJT:************** MINIMUM VALUE OF OBJECTIVE FUNCTION ******************** ******************** ******************** ************************************************************************************************************************ #OBJV:******************************************** 2279.447 **************************************************

典型值 THETA - VECTOR OF FIXED EFFECTS PARAMETERS

123456789************************************************************************************************************************ ******************** ******************** ******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ******************** ******************** FINAL PARAMETER ESTIMATE ******************** ******************** ******************** ************************************************************************************************************************ THETA - VECTOR OF FIXED EFFECTS PARAMETERS ********* TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 5.15E+01 1.05E+01 2.12E+01 4.85E+01 1.45E+01 1.34E+01

个体间变异方差矩阵OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS

12345678910111213141516171819 OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ******** ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 ETA1 + 1.88E-02 ETA2 + 0.00E+00 1.18E-02 ETA3 + 0.00E+00 0.00E+00 2.66E-02 ETA4 + 0.00E+00 0.00E+00 0.00E+00 0.00E+00 ETA5 + 0.00E+00 0.00E+00 0.00E+00 0.00E+00 4.19E-02 ETA6 + 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00

残差变异的方差（加和型和比例型）

123456789101112SIGMA - COV MATRIX FOR RANDOM EFFECTS - EPSILONS **** EPS1 EPS2 EPS1 + 2.21E-02 EPS2 + 0.00E+00 4.71E-02 1

个体内变异系数（100%）

12345678910111213141516171819202122OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS ******* ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 ETA1 + 1.37E-01 ETA2 + 0.00E+00 1.09E-01 ETA3 + 0.00E+00 0.00E+00 1.63E-01 ETA4 + 0.00E+00 0.00E+00 0.00E+00 0.00E+00 ETA5 + 0.00E+00 0.00E+00 0.00E+00 0.00E+00 2.05E-01 ETA6 + 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00

加和型和比例型残差变异系数百分比的变异系数

123456789101112 SIGMA - CORR MATRIX FOR RANDOM EFFECTS - EPSILONS *** EPS1 EPS2 EPS1 + 1.49E-01 EPS2 + 0.00E+00 2.17E-01 1

各个参数的标准误

1234567891011121314151617181920212223242526272829303132333435363738394041424344454647484950515253545556575859606162636465666768697071727374757677787980818283848586878889909192 ************************************************************************************************************************ ******************** ******************** ******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ******************** ******************** STANDARD ERROR OF ESTIMATE ******************** ******************** ******************** ************************************************************************************************************************ THETA - VECTOR OF FIXED EFFECTS PARAMETERS ********* TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 1.32E+00 4.34E-01 4.05E+00 4.20E+00 3.83E+00 4.70E+00 OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ******** ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 ETA1 + 6.01E-03 ETA2 + ......... 7.52E-03 ETA3 + ......... ......... 1.83E-02 ETA4 + ......... ......... ......... ......... ETA5 + ......... ......... ......... ......... 2.02E-02 ETA6 + ......... ......... ......... ......... ......... ......... SIGMA - COV MATRIX FOR RANDOM EFFECTS - EPSILONS **** EPS1 EPS2 EPS1 + 1.64E-03 EPS2 + ......... 1.04E-02 1 OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS ******* ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 ETA1 + 2.20E-02 ETA2 + ......... 3.46E-02 ETA3 + ......... ......... 5.61E-02 ETA4 + ......... ......... ......... ......... ETA5 + ......... ......... ......... ......... 4.93E-02 ETA6 + ......... ......... ......... ......... ......... ......... SIGMA - CORR MATRIX FOR RANDOM EFFECTS - EPSILONS *** EPS1 EPS2 EPS1 + 5.52E-03 EPS2 + ......... 2.39E-02

方差协方差矩阵

123456 ************************************************************************************************************************ ******************** ******************** ******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ******************** ******************** COVARIANCE MATRIX OF ESTIMATE ******************** ******************** ******************** ************************************************************************************************************************

NONMEN输出结果

NONMEN输出结果

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