The Special Program Comprehensive Immunization (CIM) seeks to promote and coordinate technical cooperation and partnerships to support Member States' efforts to sustainably and equitably reduce morbidity and mortality from vaccine-preventable diseases (VDPDs) through control and elimination strategies to improve the quality of life and life expectancy of the peoples of the Americas.

For over 40 years, the success of the Expanded Program on Immunization (EPI) has made the Region of the Americas a global leader in the elimination and control of vaccine-preventable diseases (VPDs), such as smallpox, polio, rubella, congenital rubella syndrome, measles, and neonatal tetanus. Since the creation of the EPI in 1977, countries have moved from using six vaccines in their national vaccination schemes, to an average of more than 16 vaccines, which represents greater protection for the population.

Within the framework of the resolution "Reinvigorating immunization as a public good for universal health" approved in 2021 by PAHO's governing bodies, CIM seeks to revitalize immunization programs in Member States by implementing innovative approaches and best practices through six lines of action: