该基因是肿瘤坏死因子超家族的成员。编码的跨膜蛋白的主要功能是诱导通过与 FAS 结合触发的细胞凋亡。 FAS/FASLG 信号通路对于免疫系统调节至关重要，包括 T 细胞的激活诱导细胞死亡 (AICD) 和细胞毒性 T 淋巴细胞诱导的细胞死亡。它还与多种癌症的进展有关。该基因的缺陷可能与某些系统性红斑狼疮 (SLE) 病例有关。已经描述了选择性剪接的转录物变体。[RefSeq 提供，2014 年 11 月]

This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of Apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]