Enzyme, Coenzyme, Apoenzyme, Holoenzyme, and Cofactor |
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Enzyme, Coenzyme, Apoenzyme, Holoenzyme, and Cofactor
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Enzyme, Coenzyme, Apoenzyme, Holoenzyme, and Cofactor are most often confusing. If you want to know about the Enzyme clearly, you must know Coenzyme, Apoenzyme, Holoenzyme, and Cofactor. Now, Enzyme, Coenzyme, Apoenzyme, Holoenzyme, and Cofactor are discussed step by step. Table of Contents EnzymeEnzymes are macromolecular, proteinous, chemical catalysts which are secreted by the exocrine glands that accelerate or catalyze all biochemical reactions in the living body. They are carried by the specific duct and generally functioned near to the glands. Wilhelm K眉hne (German physiologist) first used the term聽enzyme聽in 1877. Properties of Enzymes Protein in nature except for ribozyme Enzymes are colorless but some are blue, green, or greenish brown. Colloidal and heat liable Soluble in water They have definite isoelectric pH Don鈥檛 initiate or alter the existence of reaction Highly specific in reaction Remain chemically unchanged in the overall process Functionally independent of parent cell Inhibitor or activator modify their rate of activity. Examples of Enzyme Cellulases Papain Ligninases Rennin Proteases Lipases Amylases Trypsin Mannanases Pectinases Glucanases Nucleases Betaglucanases 聽DNA Ligase Amyloglucosidase 聽Polymerases Pullulanases Xylanases Acetolactate Decarboxylase (ALDC) 聽Hemicellulases Lignin Peroxidases ApoenzymeApoenzymes are those enzymes which require an organic or inorganic cofactor to perform their specific functions but do not have one bound. Apoenzymes also call apoproteins. In other words, Apoenzymes are enzymes that lack their necessary cofactor(s) for performing their specific function. Apoenzyme is an inactive form of some enzyme. Apoenzyme is also called a proenzyme or zymogen. 聽HoloenzymeThe Holoenzyme is the combination Apoenzyme & Cofactor that activated complex of an enzyme for a specific catalytic action. Holoenzymes are the active form of an apoenzyme. Here co-factor may be inorganic ions or organic or metallorganic (coenzyme).
Cofactors are either one or more inorganic (e.g. metal ions and iron-sulfur clusters) or a complex organic or metalloorganic (e.g. flavin and heme), non-protein chemical compounds that assist in the biochemical transformation of an Apoenzyme. Cofactors also known as “helper molecules” that assist apoenzyme during the catalysis of reactions. Some sources also limit the use of the term “cofactor” to inorganic ions. Types of cofactor聽Cofactors are divided into two broad groups: Organic cofactors, such as flavin or heme, Inorganic cofactors, such as metal ions Mg2+, Cu2+, Mn2+, or iron-sulfur clusters.
Coenzymes are small, organic or metalloorganic, non-protein molecules that are as auxiliary for the specific action of an enzyme. They act as a transient carrier of specific functional groups from enzyme to enzyme. Coenzymes bind to the apoenzyme and assist in enzyme activity. A coenzyme is technically a type of cofactor. These are relatively heat stable low molecular weight compound and highly bound to an enzyme. Most of these are vitamin B-complex derivatives. Coenzymes Derived from Vitamin B-Complex NAD, NADP Niacin CoASH Pantothenic acid FAD, FMN Riboflavin Pyridoxal phosphate Pyridoxin Thiamine phosphate Thiamine Tetrahydrofolate Folic acidYou may also read: Agonist, Partial Agonist, Antagonist, Inverse Agonist Vitamin, Pro-vitamin, Anti-vitamin Prebiotics, Probiotics, Synbiotics, Psychobiotics |
As for Example, NADH, NADPH and adenosine triphosphate (ATP), Riboflavin, Thiamine, and Folic Acid.【本文地址】
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