We examined the approximate change in CDASI-A score between two consecutive visits that would lead to a meaningful change in QoL. Literature discussing MCID (minimal clinically important difference) of the DLQI refers to meaningful change as one that demonstrates an improvement in symptoms or improvement in function according to the patient’s point of view.5,12 Previous studies and therapy guidelines have used an MCID of 5 for inflammatory skin diseases.6 We define important or meaningful change equivalently to the MCID, as one that is important in the patient’s perspective. Because approximate changes in the Symptoms and Emotions subscale scores that indicate meaningful change in QoL between two time points have not been established in the past with the creation of the Skindex-29, we derived this value by comparing the Skindex-29 and DLQI relative to the CDASI-A (Table 1). The DLQI and Skindex-29 correlate with each other (Skindex-29 Symptoms r=.6323, Skindex-29 Emotions r=.6744, Skindex-29 Function r=.8598; p