刘婷婷 |
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姓名:刘婷婷 职称:校聘副教授,硕士生导师 联系邮箱:[email protected]; [email protected] 课题组主页:http://www.x-mol.com/groups/tina-liu
学习经历: 2009.09~2013.06 延边大学药学院,药学,学士 2013.09~2018.12 山东大学药学院,药物化学,硕博连读 2017.11~2018.11 UT Southwestern Medical Center,化学生物学,访问学者
工作经历: 2019.09~至今 山东第一医科大学药学院,药物化学,校聘副教授
研究方向: 1. 靶向肿瘤小分子荧光探针的设计、合成及评价研究; 2. 靶向肿瘤的小分子抑制剂的设计、合成及评价研究。
主要学术任职: 1. 山东生物医学工程学会医美药分子工程专业委员会,委员; 2. J. Med. Chem., Eur. J. Med. Chem.等期刊审稿人
主要获奖情况: 1. 山东省课程思政示范案例三等奖,山东省高等医学教育研究中心,2021; 2. 于金明科技创新奖,山东第一医科大学,2021。
主要科研课题: 1. 国家自然科学基金青年基金项目,8210131454,新型BRD4荧光探针的构建及其在乳腺癌成像分析中的应用研究,2022.01-2024.12,30万元,主持。 2. 山东省自然科学基金青年项目,ZR2020QH344,新型环境敏感型 Mcl-1 荧光探针的设计、合成及成像应用研究,2021.01-2023.12,14万元,主持。 3. 山东省医药卫生科技发展计划项目,2019WS393,新型环境敏感型Mcl-1荧光探针的设计、合成及生物成像应用研究,2020.06-2022.06,2万元,主持。
近五年代表性论文(限第一作者和通讯作者): 1. Tingting Liu*, Shubin Song, Xu Wang, Jifu Hao. Small-molecule inhibitors of breast cancer-related targets: Potential therapeutic agents for breast cancer. European Journal of Medicinal Chemistry, 2021, 210, 112954. (IF = 7.0) 2. Zheng Zhang#, Xiaolan Xing#, Peng Guan, Shubin Song, Guirong You, Chengcai Xia, Tingting Liu*. Recent progress in agents targeting polo-like kinases: Promising therapeutic strategies. European Journal of Medicinal Chemistry, 2021, 217, 113314. (IF = 7.0) 3. Sitao Zhang, Yanzhao Chen, Chengsen Tian, Yujing He, Zeru Tian, Yichao Wan and Tingting Liu*. Dual-target inhibitors based on BRD4: Novel therapeutic approaches for cancer. Current Medicinal Chemistry, 2021, 28, 1775-1795 4. Tingting Liu*, Yichao Wan, Yuliang Xiao, Chengcai Xia, Guiyun Duan. Dual-target inhibitors based on HDACs: Novel antitumor agents for cancer therapy. Journal of Medicinal Chemistry, 2020, 63, 8977-9002. (IF = 8.0) 5. Tingting Liu*, Zhongyu Wu, Yujing He, Yuliang Xiao, Chengcai Xia. Single and dual target inhibitors based on Bcl-2: Promising anti-tumor agents for cancer therapy. European Journal of Medicinal Chemistry, 2020, 201, 112446-112458. (IF = 7.0) 6. Yichao Wan*, Chunxing Yan, Han Gao, Tingting Liu*. Small-molecule PROTACs: Novel agents for cancer therapy. Future Medicinal Chemistry, 2020, 12, 1756-8919. 7. Tingting Liu, Gaopan Dong, Feng Xu, Bowen Han, Hao Fang, YunHuang, Yubin Zhou, Lupei Du, Minyong Li*. Discovery of turn-On fluorescent probes for detecting Bcl-2 Protein. Analytical Chemistry, 2019, 91, 5722-5728. (IF = 8.0) 8. Tingting Liu, Yuqi Gao, Xiaomeng Zhang, Yichao Wan, Lupei Du, Hao Fang, Minyong Li*. Discovery of a turn-On fluorescent probe for myeloid cell leukemia‑1 protein. Analytical Chemistry, 2017, 89, 11173-11177. (IF = 8.0) 9. Tingting Liu, Yichao Wan, Renshuai Liu, Lin Ma, Minyong Li, Hao Fang*. Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors. Bioorganic & Medicinal Chemistry, 2017, 25, 1939-1948. 10. Tingting Liu#, Yan Jiang#, Zhenzhen Liu, Jin Li, Kun Fang, Chunlin Zhuang, Lupei Du, Hao Fang, Chunquan Sheng* and Minyong Li*. Environment-sensitive turn-on fluorescent probes for p53-MDM2 protein-protein interaction. MedChemComm, 2017, 8, 1727-1732.
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