豚鼠是听力研究中常用的动物模型，其可听频率范围与人类相似，在啮齿类动物中耳蜗较大。许多研究调查了顺铂对豚鼠的耳毒性作用，但这些研究大多限于单次高剂量推注顺铂。这种给药方法与人类治疗方案不一致，因此缺乏临床应用的转化价值。我们根据基于共同研究和临床方案的豚鼠测试了几种不同的顺铂给药方案，测量了由此产生的听力损失和发病率（体重减轻）。我们提出每周一次 4 mg/kg 顺铂注射剂持续三周的给药模式，以最好地模拟临床治疗方案。

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The guinea pig is a commonly-used animal model in hearing research, as their audible frequency range is similar to that of humans, and they possess comparatively large cochleae among rodents. Numerous studies have investigated the ototoxic effects of cisplatin in guinea pigs, but these have been mostly limited to single high-dose bolus injections of cisplatin. This method of drug administration is not consistent with human treatment schedules, and therefore lacks translational value to clinical applications. We tested several different cisplatin dosing schedules in guinea pigs based on common research based and clinical regimens, measuring the resulting hearing loss and morbidity (weight loss). We propose a dosing paradigm of once-weekly 4 mg/kg cisplatin injections for three weeks to best mimic clinical treatment schedules. This method resulted in a configuration of hearing loss similar to what is observed in humans along with minimal changes in weight.