通过细胞-基质相互作用和 ECM 重塑，常驻细胞和细胞外基质 (ECM) 之间的双向通讯可动态塑造组织。肿瘤利用 ECM 重塑来创造促进肿瘤发生和转移的微环境。在这篇综述中，我们关注肿瘤和肿瘤相关基质细胞如何沉积、生物化学和生物物理修饰以及降解肿瘤相关 ECM。这些肿瘤驱动的变化支持肿瘤生长，增加肿瘤细胞的迁移，并重塑远处器官的 ECM 以允许转移进展。更好地了解致瘤性 ECM 重塑的潜在机制对于开发患者治疗方法至关重要。

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Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling. Tumours leverage ECM remodelling to create a microenvironment that promotes tumourigenesis and metastasis. In this review, we focus on how tumour and tumour-associated stromal cells deposit, biochemically and biophysically modify, and degrade tumour-associated ECM. These tumour-driven changes support tumour growth, increase migration of tumour cells, and remodel the ECM in distant organs to allow for metastatic progression. A better understanding of the underlying mechanisms of tumourigenic ECM remodelling is crucial for developing therapeutic treatments for patients.