GATA binding protein 3 (GATA binding protein 3) is a transcription factor containing zinc finger structure. GATA3 not only maintains the growth and differentiation of normal breast ductal gland epithelial cells, but also plays an important role in the occurrence and development of various tumors. At present, the research on GATA3 in breast cancer is gradually moving from clinical pathological characteristics to molecular mechanisms, and its role in the invasion and metastasis of breast cancer has attracted extensive attention. The expression of GATA3 is not only closely related to the biological behavior of breast cancer cell proliferation, invasion and metastasis, but also closely related to the clinical pathological manifestations of breast cancer molecular typing, clinical prognosis and treatment response. This review summarizes the relationship between the occurrence and the development of breast cancer from two aspects of molecular mechanism research and clinical pathology.