参考文献

1.O'Connor JJ, Baughn CO, Pilote RR, Alpaugh WC, Linkenheimer WH, Maplesden DC. Tiamulin in the feed for the prevention of swine dysentery and growth promotion of growing pigs. Journal of Animal Science 1979, 49(4): 933-938.

2.EMA. CVMP Assessment Report for the Extension of a Community Marketing Authorization for Econor (EMEA/V/C/000042/X/0039), 2013. London, UK. 2013.

3.Aitken IA, Morgan JH, Dalziel R, Burch DG, Ripley PH. Comparative in vitro activity of valnemulin against porcine bacterial pathogens. Veterinary Record 1999, 144(5): 128.

4.Jacobs MR. Retapamulin: a semisynthetic pleuromutilin compound for topical treatment of skin infections in adults and children. Future Microbiology 2007, 2(6): 591-600.

5.Novak R. Are pleuromutilin antibiotics finally fit for human use? Ann N Y Acad Sci 2011, 1241: 71-81.

6.Schlunzen F, Pyetan E, Fucini P, Yonath A, Harms JM. Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin. Molecular Microbiology 2004, 54(5): 1287-1294.

7.Davidovich C, Bashan A, Auerbach-Nevo T, Yaggie RD, Gontarek RR, Yonath A. Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity. Proceedings of the National Academy of Sciences of the United States of America 2007, 104(11): 4291-4296.

8.Novak R, Shlaes DM. The pleuromutilin antibiotics: a new class for human use. Current Opinion in Investigational Drugs 2010, 11(2): 182-191.

9.Odou MF, Muller C, Calvet L, Dubreuil L. In vitro activity against anaerobes of retapamulin, a new topical antibiotic for treatment of skin infections. Journal of Antimicrobial Chemotherapy 2007, 59(4): 646-651.

10.Long KS, Poehlsgaard J, Hansen LH, Hobbie SN, Bottger EC, Vester B. Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket. Molecular Microbiology 2009, 71(5): 1218-1227.

11Kosowska-Shick K, Clark C, Credito K, McGhee P, Dewasse B, Bogdanovich T, Appelbaum PC. Single- and multistep resistance selection studies on the activity of retapamulin compared to other agents against Staphylococcus aureus and Streptococcus pyogenes. Antimicrobial Agents and Chemotherapy 2006, 50(2): 765-769.

12.Bock A, Turnowsky F, Hogenauer G. Tiamulin resistance mutations in Escherichia coli. Journal of bacteriology 1982, 151(3): 1253-1260.

13.Pringle M, Poehlsgaard J, Vester B, Long KS. Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates. Molecular Microbiology 2004, 54(5): 1295-1306.

14.Gentry DR, Rittenhouse SF, McCloskey L, Holmes DJ. Stepwise exposure of Staphylococcus aureus to pleuromutilins is associated with stepwise acquisition of mutations in rplC and minimally affects susceptibility to retapamulin. Antimicrobial Agents and Chemotherapy 2007, 51(6): 2048-2052.

15.Long KS, Poehlsgaard J, Kehrenberg C, Schwarz S, Vester B. The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics. Antimicrobial Agents and Chemotherapy 2006, 50(7): 2500-2505.

16.Kaminska KH, Purta E, Hansen LH, Bujnicki JM, Vester B, Long KS. Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria. Nucleic Acids Research 2010, 38(5): 1652-1663.

17.Pakula KK, Hansen LH, Vester B. Combined Effect of the Cfr Methyltransferase and ribosomal protein L3 mutations on resistance to ribosome-targeting antibiotics. Antimicrobial Agents and Chemotherapy 2017, 61(9): 00862-17.

18.Gentry DR, McCloskey L, Gwynn MN, Rittenhouse SF, Scangarella N, Shawar R, Holmes DJ. Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 2008, 52(12): 4507-4509.