陈倩

教授 博士生导师

    2013年获苏州大学材料科学与工程专业学士学位；2017年获苏州大学材料科学与工程专业博士学位；2017年至2018年在美国北卡罗来纳大学教堂山分校（UNC）从事博士后研究工作；2018年至2019年在美国加州大学洛杉矶分校（UCLA）从事博士后研究工作。2019年加入苏州大学功能纳米与软物质研究院，被聘为教授、博士生导师。

主要成果和贡献：    

      近年来在生物医学材料领域从事研究，发展了一系列基于生物材料的新型多功能纳米粒子，并探索了其在肿瘤多模态成像、光学治疗、免疫治疗等方面的应用；发展了多种微环境响应的生物材料，研究了其对肿瘤微环境及免疫微环境的调控，并进一步探索了其对包括免疫治疗在内的不同治疗策略的增效；设计了多种新型的局部给药系统，探索了其在肿瘤、眼部疾病、炎症、糖尿病等疾病中的应用。共发表学术论文100余篇，论文SCI总他引12000余次（数据来自Google scholar），SCI “H-index”为55。

荣誉奖励

2022          MIT Technology Review Innovators Under 35

2021          教育部青年长江学者

2021          科睿唯安-全球高被引科学家（交叉学科）

2021          Biomaterials Diversity Award for Young Investigator

2020          Biomaterials Science Emerging Investigators

2020          江苏省双创人才

2019          江苏省六大人才高峰

2019          科睿唯安-全球高被引科学家（交叉学科）

学术兼职：

Editorial board member, Matter (2021-)

Editorial board member, Nano research (2021-)

Editorial board member, Molecules (2020-)

Guest Editor, ChemMedChem (2021-)

发表论文：

https://publons.com/researcher/2939145/qian-chen/ https://scholar.google.com/citations?user=HYo3mysAAAAJ&hl=en

代表性论文：

1. Han Zhang, Kai Liu, Yimou Gong, Wenjun Zhu, Jiafei Zhu, Feng Pan, Yu Chao, Zhishen Xiao, Yanbin Liu, Xianwen Wang, Xianwen Wang, Zhuang Liu, Yang Yang*, Qian Chen*, “ Vitamin C supramolecular hydrogel for enhanced cancer immunotherapy”, Biomaterials, 287, 121673148 (2022).

2. Jun Zhou, Maoyi Li, Qiufang Chen, Xinjie Li, Linfu Chen, Ziliang Dong, Wenjun Zhu, Yang Yang*, Zhuang Liu*, Qian Chen*, “Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery”, Nat. Commun.,13, 3432 (2022).

3. Zhisheng Xiao, Ting Wei, Ruiliang Ge*, Qiaofeng Li, Bo Liu, Zhaoxin Ji, Linfu Chen, Junjie Zhu, Jingjing Shen, Zhuang Liu, Yueye Huang*, Yang Yang*, Qian Chen*, “Microfluidic Production of Zwitterion Coating Microcapsules with Low Foreign Body Reactions for Improved Islet Transplantation”, Small, 2202596 (2022).

4. Hairong Wang, Yu Chao, He Zhao, Xiuxia Zhou, Fuyong Zhang, Zheng Zhang, Zhiheng Li, Jian Pan, Jian Wang*, Qian Chen*, and Zhuang Liu*. “Smart Nanomedicine to Enable Crossing Blood–Brain Barrier Delivery of Checkpoint Blockade Antibody for Immunotherapy of Glioma”, ACS Nano, 16, 1, 664-674 (2022).

5. Longlong Tian, Ming Shao, Yimou Gong, Yu Chao, Ting Wei, Kai Yang, Qian Chen*, Zhuang Liu*. “Albumin-binding lipid-aptamer conjugates for cancer immunoimaging and immunotherapy”, Sci. China Chem., 65,574-583 (2021).

6. Muchao Chen, Yanjun Tan, Jiaying Hu, Yanping Jiang, Zixian Wang, Zhuang Liu, Qian Chen*. “Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation” Small, 2104773 (2021).

7. Han Zhang, Wenjun Zhu, Qiutong Jin, Feng Pan, Jiafei Zhu, Yanbin Liu, Linfu Chen, Jingjing Shen, Yang Yang*, Qian Chen*, and Zhuang Liu*. “Inhalable nanocatchers for SARS-CoV-2 inhibition”, Proc. Natl. Acad. Sci. U.S.A., 118(29): e2102957118 (2021).

8. Jiaying Hu, Ting Wei, Jiafei Zhu, He Zhao, Zhaoxin Ji, Muchao Chen, Qiutong Jin, Jingjing Shen, Yanjun Tan, Yikai Han, Han Zhang, Nailin Yang, Linfu Chen, Zhisheng Xiao, Zhuang Liu and Qian Chen*. “Mechanically active adhesive and immune regulative dressings for wound closure”, Matter., 4 (9), 2985-3000 (2021).

9. Jiafei Zhu, Qiutong Jin, He Zhao, Wenjun Zhu, Zhuang Liu, Qian Chen*. “Reactive Oxygen Species Scavenging Sutures for Enhanced Wound Sealing and Repair”, Small Structures, 2(7), 2100002 (2021).

10. Qiutong Jin, Wenjun Zhu, Jiafei Zhu, Junjie Zhu, Jingjing Shen, Zhuang Liu, Yang Yang*, Qian Chen*. “Nanoparticle-mediated delivery of inhaled immunotherapeutics for treating lung metastasis”, Adv. Mater., 2007557 (2021).

11. Wenjun Zhu, Qian Chen*, Qiutong Jin, Yu Chao, Lele Sun, Xiao Han, Jun Xu, Longlong Tian, Jinglei Zhang, Teng Liu, Zhuang Liu*. “Sonodynamic therapy with immune modulatable two-dimensional coordination nanosheets for enhanced anti-tumor immunotherapy” Nano Res., 14, 212 (2021)

12. Qiutong Jin, Zhuang Liu, Qian Chen*, “Controlled release of immunotherapeutics for enhanced cancer immunotherapy after local delivery”, J. Control. Release, DOI: 10.1016/j.jconrel.2020.10.019 (2020).

13. Yimou Gong, Muchao Chen, Yanjun Tan, Jingjing Shen, Qiutong Jin, Wutong Deng, Jian Sun*, Chao Wang, Zhuang Liu, Qian Chen*, “Injectable Reactive Oxygen Species-Responsive SN38 Prodrug Scaffold with Checkpoint Inhibitors for Combined Chemoimmunotherapy”, ACS Appl. Mater. Interfaces, 12, 45, 50248 (2020)

14. Fei Gong, Muchao Chen, Nailin Yang, Ziliang Dong, Longlong Tian, Yu Hao,  Mingpeng Zhuo, Zhuang Liu, Qian Chen*, Liang Cheng*.”Bimetallic Oxide FeWOX Nanosheets as Multifunctional Cascade Bioreactors for Tumor Microenvironment‐Modulation and Enhanced Multimodal Cancer Therapy”, Adv. Funct. Mater., 2002753 (2020)

15. Muchao Chen, Yanjun Tan, Ziliang Dong, Jiaqi Lu, Xiao Han, Qiutong Jin, Wenjun Zhu, Jingjing Shen, Liang Cheng, Zhuang Liu*, Qian Chen*. ”Injectable Anti-inflammatory Nanofiber Hydrogel to Achieve Systemic Immunotherapy Post Local Administration” Nano Lett., 20, 9, 6763 (2020)

16. Qian Chen*, Muchao Chen and Zhuang Liu*. “Local biomaterials-assisted cancer immunotherapy to trigger systemic antitumor responses”, Chem. Soc. Rev., 48, 5506-5526 (2019)

17. Yu Chao, Qian Chen*, Zhuang Liu*. “Smart Injectable Hydrogels for Cancer Immunotherapy”, Adv. Funct. Mater.,1902785 (2019)

18. Wenjun Zhu, Jiayue Zhao, Qian Chen*, Zhuang Liu*. “Nanoscale metal-organic frameworks and coordination polymers as theranostic platforms for cancer treatment” Coordin. Chem. Rev., 398, 113009 (2019)

19. Qian Chen*†, Guojun Chen†, Jiawen Chen, Jingjing Shen, Xudong Zhang, Jinqiang Wang, Amanda Chan, Zhen Gu*. “Bioresponsive Protein Complex of aPD1 and aCD47 Antibodies for Enhanced Immunotherapy”, Nano Lett., 19, 4879 (2019).

20. Qian Chen, Quanyin Hu, Elena Dukhovlinova, Guojun Chen, Sarah Ahn, Chao Wang, Edikan Ogunnaike, Frances S. Ligler, Gianpietro Dotti*, Zhen Gu*. “Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells”, Adv. Mater., 31, 1900192 (2019).

21. Qian Chen, Chao Wang, Xudong Zhang, Quanyin Hu, Hongjun Li, Guojun Chen, Jinqiang Wang, Di Wen, Yuqi Zhang, Guang Yang, Jun Wang, Gianpietro Dotti, and Zhen Gu1*. “In Situ Sprayed Bioresponsive Immunotherapeutic Gel for Post-Cancer Surgical Treatment”, Nat. Nanotechnol., 14, 89–97 (2019).

22. Qian Chen, Jiawen Chen, Zhijuan Yang, Jun Xu, Ligeng Xu, Chao Liang, Xiao Han, Zhuang Liu*, “Nanoparticle-enhanced radiotherapy to trigger robust cancer immunotherapy”, Adv. Mater., 31(10), 180228 (2019).

23. Zhijuan Yang, Qian Chen*, Jiawen Chen, Ziliang Dong, Rui Zhang, Jingjing Liu, Zhuang Liu*, Tumor-pH-Responsive Dissociable Albumin-Tamoxifen Nano-complexes Enabling Efficient Tumor Penetration and Hypoxia Relief for Enhanced Cancer Photodynamic Therapy Small, 14(49), 1803262, 2018.

24. Qian Chen, Chao Liang, Xiaoqi Sun, Jiawen Chen, Zhijuan Yang, He Zhao, Liangzhu Feng, and Zhuang Liu*. “H2O2-responsive Liposomal Nanoprobe for Photoacoustic Inflammation Imaging and Tumor Theranostics via In Vivo Chromogenic Assay”, Proc. Natl. Acad. Sci. U.S.A., 114(21), 5343-5348 (2017).

25. Qian Chen†, Ligeng Xu†, ChaoLiang, Chao Wang, Rui Peng, and Zhuang Liu*. “Photothermal Therapy with Immune-adjuvant Nanoparticles Together with Checkpoint Blockade for Effective Cancer Immunotherapy”, Nat. Commun., 7, 13193 (2016).

26. Qian Chen, Liangzhu Feng, Jingjing Liu, Wenwen Zhu, Ziliang Dong, Yifan Wu, Zhuang Liu* “Intelligent Albumin–MnO2 Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy”, Adv. Mater., 28, 7129-7136 (2016).

27. Qian Chen, Zhuang Liu* “Albumin carriers for cancer theranostics: a conventional platform with new promises”, Adv. Mater., 28, 10557-10566 (2016).

28. Qian Chen, Xiaodong Liu, Jiawen Chen, Jianfeng Zeng*, Zhenping Cheng, Zhuang Liu* “A Self-assembled Albumin-based Nanoprobe for in vivo Ratiometric Photoacoustic pH Imaging”, Adv. Mater., 27, 6820–6827 (2015).

29. Qian Chen, Xin Wang, Chao Wang, Liangzhu Feng, Yonggang Li, Zhuang Liu* “Drug-Induced Self-Assembly of Modified Albumins as Nano-theranostics for Tumor-Targeted Combination Therapy”, ACS Nano, 9, 5223-5233 (2015).

30. Qian Chen, Chao Liang, Chao Wang, Zhuang Liu*, “An Imagable and Photothermal “Abraxane-Like” Nanodrug for Combination Cancer Therapy to Treat Subcutaneous and Metastatic Breast Tumors”, Adv. Mater., 27, 903-910 (2015).

联系方式：

E-mail: [email protected]