2,6-吡啶甲酸(DPA)作为炭疽杆菌的生物标志物的检测引起了广泛关注。在之前的DPA检测报道中，荧光探针可能特异性不高。因此，合理设计和开发性能优良的荧光传感器对于DPA的检测具有重要意义。在本研究中，以3-多氟联苯-3',4,5'-三羧酸（H2FPTA）为配体，通过水热法合成了两种新型镧系金属有机骨架（Ln-MOF）。研究表明，Ln-MOFs可以实时检测DPA，检测限分别为0.54 μM和0.67 μM，并且在胎牛血清中具有较高的回收率（95 % -108 %）。作为自校准传感器，可以通过二维荧光码图清晰地区分血液中的其他物质。将 Ln-MOF 纺成纳米纤维膜后，它们对 DPA 做出快速响应。这增加了实用性，并为开发简单高效的比率传感器提供了一个有前途的想法。

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The detection of 2,6-pyridinecarboxylic acid (DPA), as a biomarker of Bacillus anthracis, has attracted wide attention. In previous reports of DPA detection, fluorescent probes may not have high specificity. Therefore, the rational design and development of fluorescent sensors with excellent performance is of great significance for the detection of DPA. In this study, two novel lanthanide metal–organic frameworks (Ln-MOFs) were synthesized by hydrothermal method using 3-polyfluorobiphenyl-3 ', 4,5 ' -tricarboxylic acid (H2FPTA) as ligand. Studies have shown that Ln-MOFs can detect DPA in real time, with detection limits of 0.54 μM and 0.67 μM, respectively, and have a high recovery rate (95 % −108 %) in fetal bovine serum. As a self-calibration sensor, other substances in the blood can be clearly distinguished by a two-dimensional fluorescence code diagram. After the Ln-MOFs were spun into nanofiber membranes, they responded quickly to DPA. This increases practicability and provides a promising idea for the development of simple and efficient ratio sensors.