［1］Montminy MR, Bilezikjian LM. Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene ［J］. Nature, 1987, 328 (6126):175-178. ［2］Deng L, Li Y, Huang JM, et al. Effects of p-CREB-1 on transforming growth factor-beta3 auto-regulation in hepatic stellate cells ［J］. J Cell Biochem, 2011, 112 (4):1046-1054. ［3］Kitagawa`K, Sasaki T, Terasaki Y, et al. CREB activation is a key player for ischemic tolerance in the brain ［J］. Rinsho Shinkeigaku, 2012, 52 (11):904-907. ［4］Klinz FJ, Korkmaz Y, Cho B, et al. Transcription factor CREB is phosphorylated in human molar odontoblasts and cementoblasts in vivo ［J］. Histochem Cell Biol, 2013, 139 (4):615-620.［5］Wang P, Xu J, Zhang C. CREB, a possible upstream regulator of Bcl-2 in trichosanthin-induced HeLa cell apoptosis ［J］. Mol Biol Rep, 2010, 37 (4):1891-1896. ［6］Wang P, Huang S, Wang F, et al. Cyclic AMP-response element regulated cell cycle arrests in cancer cells ［J］. PloS One, 2013, 8 (6):e65661. ［7］Wang WL, Wang P, Wang F, et al. Effects of RhoA/ROCKI signal pathway on the taxol-induced cell-cycle arrest of cervical cancer cells ［J］. Acta Anatomica Sinica, 2013, 44 (4):485-491. (in Chinese) 王维莉, 王萍, 王峰, 等. RhoA/ROCK信号通路在紫杉醇诱导宫颈细胞周期阻滞中的作用 ［J］. 解剖学报, 2013, 44 (4):485-491. ［8］Shu CH, Yang WK, Shih YL, et al. Cell cycle G2/M arrest and activation of cyclin-dependent kinases associated with low-dose paclitaxel-induced sub-G1 apoptosis ［J］. Apoptosis, 1997, 2 (5):463-470. ［9］Park JE, Woo SR, Kang CM, et al. Paclitaxel stimulates chromosomal fusion and instability in cells with dysfunctional telomeres: implication in multinucleation and chemosensitization ［J］. Biochem Biophys Res Commun, 2011, 404 (2):615-621. ［10］Yang J, Kornbluth S. All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners ［J］. Trends Cell Biol, 1999, 9 (6):207-210. ［11］John PC, Mews M, Moore R. Cyclin/Cdk complexes: their involvement in cell cycle progression and mitotic division ［J］. Protoplasma, 2001, 216 (3-4):119-142. ［12］Canavese M, Santo L, Raje N. Cyclin dependent kinases in cancer: potential for therapeutic intervention ［J］. Cancer Biol Ther, 2012, 13 (7):451-457. ［13］Kahl CR, Means AR. Regulation of cell cycle progression by calcium/calmodulin-dependent pathways ［J］. Endocr Rev, 2003, 24 (6):719-736. ［14］Farras R, Baldin V, Gallach S, et al. JunB breakdown in mid-/late G2 is required for down-regulation of cyclin A2 levels and proper mitosis ［J］. Mol Cell Biol, 2008, 28 (12):4173-4187. ［15］Khandelwal P, Padala MK, Cox J, et al. The N-terminal domain of y-box binding protein-1 induces cell cycle arrest in G2/M phase by binding to cyclin D1 ［J］. Int J Cell Biol, 2009, 2009:243532. ［16］Ling YH, Consoli U, Tornos C, et al. Accumulation of cyclin B1, activation of cyclin B1-dependent kinase and induction of programmed cell death in human epidermoid carcinoma KB cells treated with taxol ［J］. Int J Cancer, 1998, 75 (6):925-932. ［17］Shi K, Jiang Q, Li Z, et al. Sodium selenite alters microtubule assembly and induces apoptosis in vitro and in vivo ［J］. J Hematol Oncoly, 2013, 6:7. ［18］Xiao X, Li BX, Mitton B, et al. Targeting CREB for cancer therapy: friend or foe ［J］. Curr Cancer Drug Targets, 2010, 10 (4):384-391. ［19］Tan X, Wang S, Zhu L, et al. cAMP response element-binding protein promotes gliomagenesis by modulating the expression of oncogenic microRNA-23a ［J］. Proc Nat Acad Sci USA, 2012, 109 (39):15805-15810. ［20］Li D, Jin L, Alesi GN, et al. The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis ［J］. J Biol Chem, 2013, 288 (45):32528-32538. ［21］Nakayama K. cAMP-response element-binding protein (CREB) and NF-kappaB transcription factors are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1 ［J］. J Biol Chem, 2013, 288 (31):22584-22595. ［22］Kinjo K, Sandoval S, Sakamoto KM, et al. The role of CREB as a proto-oncogene in hematopoiesis ［J］. Cell Cycle, 2005, 4 (9):1134-1135. ［23］Abramovitch R, Tavor E, Jacob-Hirsch J, et al. A pivotal role of cyclic AMP-responsive element binding protein in tumor progression ［J］. Cancer Res, 2004, 64 (4):1338-1346. ［24］Dworet JH, Meinkoth JL. Interference with 3’,5’-cyclic adenosine monophosphate response element binding protein stimulates apoptosis through aberrant cell cycle progression and checkpoint activation ［J］. Mol Endocrinol, 2006, 20 (5):1112-1120. ［25］Kamiya K, Sakakibara K, Ryer EJ, et al. Phosphorylation of the cyclic AMP response element binding protein mediates transforming growth factor beta-induced downregulation of cyclin A in vascular smooth muscle cells ［J］. Mol Cell Biol, 2007, 27 (9):3489-3498. ［26］Bottazzi ME, Buzzai M, Zhu X, et al. Distinct effects of mitogens and the actin cytoskeleton on CREB and pocket protein phosphorylation control the extent and timing of cyclin A promoter activity ［J］. Mol Cell Biol, 2001, 21 (22):7607-7616. ［27］Andreatta CP, Nahreini P, Hanson AJ, et al. Regulated expression of VP16CREB in neuroblastoma cells: analysis of differentiation and apoptosis ［J］. J Neurosci Res, 2004, 78 (4):570-579. ［28］Rozenberg J, Rishi V, Orosz A, et al. Inhibition of CREB function in mouse epidermis reduces papilloma formation ［J］. Mol Cancer Res, 2009, 7 (5):654-664. ［29］An Q, Zhang YH, Liu X, et al. Paclitaxel’s effect on lung cancer A549 cells and its changes on luciferase value of nuclear transcription factors ［J］. Journal of Nanjing University of Traditional Chinese Medicine, 2011, 27 (3):254-256. (in Chinese) 安青, 章永红, 刘旭, 等. 紫杉醇作用于肺癌A549细胞核转录因子荧光素酶值变化的意义 ［J］. 南京中医药大学学报，2011, 27 (3):254-256.