在此，多巴胺（DA）通过席夫碱还原反应与氧化海藻酸钠（OSA）接枝，旨在制造具有增强生物相容性和适合临床应用粘附性的新型DA接枝OSA（OSA-DA）水凝胶。OSA-DA 的化学结构通过 UV-Vis、FTIR 和1表征H NMR光谱分析。研究了水凝胶特性、生物相容性以及慢性糖尿病伤口愈合效果。结果表明DA与OSA成功接枝，最高接枝率为7.50%。此外，OSA-DA 水凝胶具有合适的溶胀比和合适的粘附特性。此外，OSA-DA 在 L-929 细胞中表现出令人满意的细胞相容性和细胞亲和力，在 SD 大鼠中表现出优异的生物相容性。此外，OSA-DA对人脐静脉内皮细胞（HUVECs）的迁移和管形成具有显着的促进作用。对全层切除慢性糖尿病伤口的研究进一步表明，OSA-DA 水凝胶可以通过促进血管生成、减少炎症反应和刺激胶原蛋白沉积来加速愈合。

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Herein, the dopamine (DA) was grafted with oxidized sodium alginate (OSA) via Schiff base reduction reaction, aiming to fabricate novel DA-grafted OSA (OSA-DA) hydrogels with enhanced biocompatibility and suitable adhesion for clinical applications. The chemical structures of OSA-DA were characterized via UV–Vis, FTIR and 1H NMR spectroscopy analysis. The hydrogel characteristics, biocompatibility, as well as the chronic diabetic wound healing efficacy were investigated. Our results demonstrated that DA was grafted with OSA successfully with highest grafting rate of 7.50%. Besides, OSA-DA hydrogels possessed suitable swelling ratio and appropriate adhesion characteristics. Additionally, OSA-DA exhibited satisfactory cytocompatibility and cell affinity in L-929 cells, and superior biocompatibility in SD rats. Moreover, OSA-DA exerted remarkable promoting effects on migration and tube formation of human umbilical vein endothelial cells (HUVECs). Studies on full-thickness excision chronic diabetic wounds further revealed that OSA-DA hydrogels could accelerate healing via promoting angiogenesis, reducing inflammation response, and stimulating collagen deposition. Overall, our studies would provide basis for SA-based hydrogels as clinical wound dressings.