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河豚毒素的性质及应用研究进展
2021, 43(5): 539-548. doi: 10.14012/j.cnki.fjsc.2021.05.013 河豚毒素的性质及应用研究进展王纯纯 1 , 乔琨 2 , 陈贝 2 , 许旻 2 , 黄鹭强 1 , 刘智禹 2 1. 福建师范大学生命科学学院, 福建 福州 350108; 2. 福建省水产研究所, 国家海水鱼类加工技术研发中心, 福建省海洋生物增养殖与高值化利用重点实验室, 福建 厦门 361013
收稿日期：2021-06-21 网络出版日期： 基金项目: 福建省省属公益类科研院所基本科研专项（2020R1013008）；2019年度福建省海洋经济发展专项. 关键词： 河豚毒素 , 来源 , 富集 , 耐受 , 应用 Research progress on the properties and application of tetrodotoxinWANG Chunchun 1 , QIAO Kun 2 , CHEN Bei 2 , XU Min 2 , HUANG Luqiang 1 , LIU Zhiyu 2 1. College of Life Sciences, Fujian Normal University, Fuzhou 350108, China; 2. National Research and Development Center for Marine Fish Processing, Key Laboratory of Cultivation and High-value Utilization of Marine Organisms in Fujian Province, Fisheries Research Institute of Fujian, Xiamen 361013, China
Received Date：2021-06-21 Web Publishing Date：
Keywords： tetrodotoxin , origin , enrichment , tolerance , application 摘要 参考文献河豚毒素是一种毒性极强的生物碱，稳定性强、亲水性强。河豚毒素来源尚未明确，但相关证据表明河豚毒素可能产生于外界与微生物的共同作用。河豚毒素拥有特异阻断神经的功能，因此人们极为关注河豚毒素在临床与神经学研究领域的发展。河豚毒素具有很高的研究价值，一方面，基于河豚毒素的富集、耐受特点可开发解毒试剂，另一方面，河豚毒素作为钠离子通道阻断剂可研发神经性治疗新药物。未来可进一步深入研究河豚毒素的富集、耐受机制，改善和丰富应用等。本文概括了河豚毒素的理化性质、来源、富集和耐受等内容，以及河豚毒素的应用研究进展，旨在为完善河豚毒素研究体系提供参考。 Tetrodotoxin is an extremely toxic alkaloid that is highly stable and hydrophilic.The source of tetrodotoxin is not known, but evidence suggests that tetrodotoxin may arise from a combination of external and microbial sources.Tetrodotoxin possesses specific nerve-blocking properties and therefore there is great interest in the development of tetrodotoxin in the field of clinical and neurological research.Tetrodotoxin has great research value.On the one hand, based on the enrichment and tolerance characteristics of tetrodotoxin we can develop detoxification reagents, and on the other hand, tetrodotoxin can be used as a sodium channel blocker to develop new drugs for neurological treatment.Future research on tetrodotoxin can further investigate its enrichment, tolerance mechanism, improvement and enrichment applications.In this paper, we intend to give an overview of the physicochemical properties, sources, enrichment and tolerance of tetrodotoxin and the progress of tetrodotoxin application research, aiming to provide a reference for improving the tetrodotoxin research. 参考文献 [1] Jorge L, Laura R, B Lucía, et al.Tetrodotoxin, anextremely potent marine neurotoxin:distribution, toxicity, origin and therapeutical uses[J].Marine Drugs, 2015, 13(10):6384-6406. 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