题组负责人

周芳芳教授，国家杰青(2021)、长江青年学者(2017)

诚聘博士后，年薪四十万起可晋升；

诚聘副教授/研究员/副研究员，年薪四十万起可晋升；

研究方向：包括但不限于结构生物学、生物信息学、感染、免疫、肿瘤、信号转导等方向。

要求：工作自觉上进、有志于科学研究、有创新思维、甘于寂寞、敢于突破和探索、勇于创造。有意向者请联系:  [email protected]

周芳芳2008年毕业于清华大学生物科学与技术系并获博士学位。2008-2013年在荷兰莱顿大学医学中心先后任职博士后、研究员。2013-2014年在荷兰莱顿大学医学中心任研究助理教授。2014年10月受聘苏州大学生物医学研究院特聘教授及博士生导师。周芳芳实验室致力于固有免疫响应的分子机制研究，取得了多项科研成果。独立开展工作后以通讯或共同通讯在国内外期刊如Cell (2024)、Nature Immunology（2017, 2018, 2022）、Nature Cell Biology（2012, 2021）、Molecular Cell（2013, 2020）、Nature Structural & Molecular Biology (2023)、Nature Communications (2017, 2022)、EMBO Journal (2022)、Trends in Biochemical Sciences (2013)、Advanced Materials（2021）、Cell Reports (2022)、Advanced Science (2019, 2020a, 2020b, 2021, 2022a, 2022b, 2023a, 2023b)、Signal Transduction and Targeted Therapy (2020a, 2020b, 2020c, 2021a, 2021b, 2022a, 2022b, 2022c, 2022d, 2023a, 2023b, 2023c, 2023d)、Molecular Cancer (2021)、Cell Death & Differentiation (2017)、Protein Cell (2014)、Cancer Research (2016)、Cell & Molecular Immunology (2020, 2021, 2022)、J Mol Cell Biol (2022, 2023)、MedComm (2022a, 2022b, 2023a, 2023b)、Molecular Biomedicine (2022a, 2022b)、Frontiers in Immunology (2021) 和MBoC（2011）等发表论文80余篇。

主要研究方向:

1. 固有免疫响应的分子机制和生理、病理调控；

2. 固有免疫防御病毒的机制及干预策略；

3. 肿瘤发生和逃脱固有免疫监视的分子机制；

代表性论文（*Corresponding author）:

1. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis. Zong Z, Xie F, et al., Zhou F*. Cell. 2024

2. TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence. Ren J, Wang S, Zong Z, Pan T, et al., He X, Zhou F*, Zhang L*. Nature Communications. 2024 

3. iProPhos: A Web-Based Interactive Platform for Integrated Proteome and Phosphoproteome Analysis. Zou J, Qin Z, Li R*, et al., Zhou F*, Zhang L*. Molecular Cellular Proteomics. 2024

4. TBK1: a new target for overcoming cancer immunotherapy resistance. Guan J, Zhang L*,  Zhou F*. Science China Life Sciences. 2024

5. DeSUMOylation by SENP1 inhibits MAVS aggregation and antagonizes IRF3 activation. Dai T, Zhang L, Ran Y, et al., Lin S*, Zhang L*, Zhou F*. Nature Structure & Molecular Biology. 2023

6. Capturing Protein-Protein Interactions with Acidic Amino Acids Reactive Cross-Linkers. Liao QQ, Shu X, Sun W, Mandapaka H, Xie F, Zhang Z, Dai T, Wang S, Zhao J, Jiang H, Zhang L, Lin J, Li SW, Coin I, Yang F, Peng J, Li K*, Wu H*, Zhou F*, Yang B*. Small. 2023

7. The role of TIA1 and TIAL1 in germinal center B cell function and survival. Wang Y, Liu J, Zhou F*. Cellular Molecular Immunology. 2023

8. Biomolecular condensates: formation mechanisms, biological functions and therapeutic targets. Niu X, Zhang L, Wu Y, et al., Liu J*, Zhang L*, Zhou F*. MedComm. 2023

9. Deciphering dynamic changes of the aging transcriptome with COVID-19 progression and convalescence in the human blood. Li R, Zou J, Pei D, Pan T, et al., Chen Y*, Zhou F*, Zhang L*. Signal Transduction and Targeted Therapy. 2023

10. The loss of epigenetic information: not only consequences but a cause of mammalian aging. Pan C, Zhou F*, Zhang L*. Signal Transduction and Targeted Therapy. 2023

11.  The fungal mycobiome: a new hallmark of cancer revealed by pan-cancer analyses. Z Zong, Zhou F*, Zhang L*. Signal Transduction and Targeted Therapy. 2023

12. Motile cilia and microvillar: accomplices of SARS-CoV-2 in penetrating mucus barrier and infecting airway epithelium. Su P, Zhou F*, Zhang L*. Signal Transduction and Targeted Therapy. 2023

13. A review of gut microbiota-derived metabolites in tumor progression and cancer therapy. Yang Q, Wang B, Zheng Q, et al., Meng X*, Zhou F*, Zhang L*. Advanced Science. 2023

14. A review of extracellular vesicles in COVID-19 diagnosis, treatment and prevention. Su P, Wu Y, Xie F, Zeng Q, et al., Meng X*, Zhou F*, Zhang L*. Advanced Science. 2023

15. WNK1, a molecular crowding sensor, links phase separation to cellular physiological stress.  Lan T, Zhou F*, Zhang L*. MedComm. 2023

16. Breast Cancer Cell-derived Extracellular Vesicles Promote CD8+ T cell Exhaustion via TGF-β type II receptor Signalling. Xie F, Zhou X, et al., Zhang L*, Zhou F*. Nature Communications. 2022

17. LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation. Wang S, et al., Zhang L*, Zhou F*. Cell Reports. 2022

18. Emerging implications of phase separation in cancer. Ren J, Zhang Z, Zong Z, Zhang L*, Zhou F*. Advanced Science. 2022

19. Wang Y，Fang X, Wang S, Wang B, Chu F, Zhang L*, Zhou F*. The role of O-GlcNAcylation in innate immunity and inflammation. Journal of Molecular Cell Biology. 2022 

20. Wang B, Zhang L, Zhou F*. Zhang L*. Potential mechanisms by which impaired ketogenesis links metabolism to T-cell dysfunction in patients with severe COVID-19. Medcomm. 2022

21. Deactylation by SIRT1 enables liquid-liquid phase separation of IRF3/7 in innate antiviral immunity. Qin Z, Fang X, et al., Zhou F*, Zhang L*. Nature Immunology. 2022

22. IRF3 and IRF7 require SIRT1 for liquid-liquid phase separation and transactivation of INF-I. Zhou F*, Zhang L*. Nature Immunology (Research Briefing). 2022

23. Targeting USP8 inhibits Cancer Progression and Prevents Extracellular-Vesicle TβRII-Induced Exhaustion of CD8+ T cells. Xie F, Zhou X, et al., Zhou F*, Zhang L*. EMBO Journal. 2022

24. Microbiota in tumors: from understanding to application. Xie Y, Xie F, Zhou X, et al., Zhang L*,  Zhou F*. Advanced Science. 2022

25. SARS-CoV-2 Omicron variant: recent progress and future perspectives. Fan Y, Li X, Zhang L, Wan S, Zhang L*,  Zhou F*. Signal Transduction and Targeted Therapy. 2022

26. Cuproptosis: a new form of programmed cell death. Wang Y, Zhang L, Zhou F*. Cellular & Molecular Immunology. 2022

27. Guan J, Zhang L*, Zhou F*. PI3K-PANK4: a new target for de novo synthesis of coenzyme A. Molecular Biomedicine. 2022

28. Wei X, Xie F, Zhou X, Yan H, Liu T, Huang J*, Wang F*, Zhou F*, Zhang L*. Developments in the understanding of pyroptosis and its potential role in the treatment of inflammation and cancer. Cellular & Molecular Immunology. 2022

29. SUMOylation in Viral Replication and Antiviral Defense. Fan Y, Li X, Zhang L,et al., Zhang L*,  Zhou F*. Advanced Science. 2022

30. STING, a critical contributor to SARS-CoV-2 immunopathology. Li H, Zhou F*, Zhang L*. Signal Transduction and Targeted Therapy. 2022

31. Ferroptosis in cancer and cancer immunotherapy. Zhao L, Zhou X, Xie F, Zhang L, et al., Zhou F*, Chen J*, Zhang L*. Cancer Communications. 2022

32. Novel pyroptosis-independent functions of gasdermins. Qin Z, Zhou F*, Zhang L*. Signal Transduction and Targeted Therapy. 2022

33. Post-translational modifications in liquid-liquid phase separation: a comprehensive review. Li J, Zhang M, et al., Zhou F*, Zhang L*. Molecular Biomedicine. 2022

34. Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions. Wang B, Zhang L, et al., Zhou F*, Zhang L*. Signal Transduction and Targeted Therapy. 2022

35. ADP-riboxanation: a new pyroptosis evasion strategy. Li H, Zhou F*, Zhang L*. J Mol Cell Biol. 2022

36. Wang S, Dai T, Qin Z, Pan T, et al., Zhou F*. Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity via elevating MAVS activity. Nature Cell Biology. 2021

37. Xie F, Su P, Pan T et al., Zhang L*, Zhou F*. Engineering extracellular vesicles enriched with palmitoylated ACE2 as COVID-19 therapy. Advanced Materials. 2021

38. ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A Review. Zhang M, et al., Zeng L*,  Zhou F*. Front Cell Dev Biol. 2021

39. Wang B, Dai T, Ren J, et al., Zhou F*.Protein N-myristoylation: functions and mechanisms in control of innate immunity.Cellular & Molecular Immunology. 2021

40. Zong Z, Wei Y, Ren J, et al., Zhou F*. The intersection of COVID-19 and cancer: signaling pathways and treatment implications. Molecular Cancer. 2021

41. Xie Y, Xie F, Zhou F*. Targeted anti-tumor immunotherapy using tumor infiltrating cells. Advanced Science. 2021

42. Dong Y, Dai T, Wang B, Zhou F*. The way of SARS-CoV-2 vaccine development: success and challenges.Signal Transduction and Targeted Therapy.2021

43. Fan Y, Zhang L*, Zhou F*. cGAS-like receptors: new RNA sensors in Drosophila. Signal Transduction and Targeted Therapy.2021

44. Guo H, Zhou L, et al., Zhou F*. Promising immunotherapies against COVID-19. Advanced Therapeutics. 2021

45. Zhang Y, Qin Z, Sun W, Chu F, Zhou F*.Function of Protein S-Palmitoylation in Immunity and Immune-Related Diseases.Frontiers in Immunology. 2021

46. Gao L, Zhou F*.Comprehensive Analysis of RUNX and TGF-β Mediated Regulation of Immune Cell Infiltration in Breast Cancer.Frontiers in Cell and Developmental Biology. 2021

47. Zhang Z, Fang X, et al., Zhou F*. Acetylation-dependent deubiquitinase OTUD3 controls MAVS activation in innate antiviral immunity. Molecular Cell. 2020

48. Dong Y, Dai T, Wei Y, et al., Zheng M*, Zhou F*. A systematic review of SARS-CoV-2 vaccine candidates. Signal Transduction and Targeted Therapy. 2020

49. Zhou X, Xie F, Wang L, et al., Zhou F*. The function and clinical application of extracellular vesicles in innate immune regulation. Cellular & Molecular Immunology. 2020

50. Wang S*, Zhou L, et al., Zhou F*. The Crosstalk Between Hippo-YAP Pathway and innate Immunity. Frontiers in Immunology. 2020

51. Dong Y, Dai T, et al.,Zhou F*. Coronavirus in continuous flux: from SARS-CoV to SARS-CoV-2.  Advanced Science. 2020

52. Zong Z, Zhang Z, et al.,Zhou F*. The functional deubiquitinating enzymes in control of innate antiviral immunity. Advanced Science. 2020

53. Jin K, et al., Zhou F*. An Effective Platform for Cancer Immunotherapy: Pooled Knockin Targeting for Genome Engineering Immunotherapies. Signal Transduction and Targeted Therapy. 2020

54. Cheng Z, Dai T, et al.,Zhou F*. The interaction between cGAS-STING pathway and pathogens. Signal Transduction and Targeted Therapy. 2020

55. Zhou L, Zhang Y, et al.,Zhou F*. A dual role of type I interferons in antitumor immunity. Advanced Biosystems. 2020

56. Xie F, Zhou X, Fang MY, et al.,Zhou F*. Extracellular Vesicles in Cancer Immune Microenvironment and Cancer Immunotherapy. Advanced Science. 2019

57. Gao L, Wang L, Dai T, Jin K, Zhang Z, et al.,Zhou F*, Zhang L*. Tumor-derived exosomes antagonize innate antiviral immunity. Nature Immunology. 2018

58. Wang S, et al., Zhang L*, Zhou F*. YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through kinase-IKKe mediated phosphorylation. Nature Immunology. 2017

59. Zhang L*, Xie F, et al., Zhou F*. SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death. Cell Death Differentiation. 2017

60. Xie F, Jin K, Shao L, et al., Zhou F*, Zhang L*. FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis. Nature Communications. 2017

61. Li Y, et al., Zhou F*, Zhang L*. c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/beta-Catenin/Axin2 Pathway. Cancer Research. 2016

62. Zhang J, et al., Zhang L*, Zhou F*. The regulation of TGF-β/SMAD signaling by protein deubiquitination. Protein Cell. 2014

63. Zhang L*,Zhou F*, ten Dijke P*. (2013) Signaling interplay between transforming growthfactor-β receptor and PI3K/AKT pathways in cancer. Trends in Biochemical Sciences. 2013

64. Zhang L,Zhou F*, et al., Ten Dijke P*. TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis. Molecular Cell. 2013

65. Zhang L, Zhou F*, et al., ten Dijke P*. (2012) USP4 is regulated by Akt phosphorylation and directly deubiquitinates TGF-β type Ireceptor. Nature Cell Biology. 2012

66. Zhang L,Zhou F*, et al., Fas-associated factor 1 antagonizes Wnt signaling by promoting β-catenin degradation. Molecular Biology of the Cell. 2011

E-mail: [email protected]

Office：Dushu lake 703-B314 

课题组成员

王帅 研究员 博导

王帅博士于2010年获得山东大学生物化学与分子生物学博士学位。2010年加中国科学院武汉病毒研究所担任助理研究员职位。2013年加入苏州大学生物医学研究院，目前担任周芳芳课题组副研究员职位。

谢枫 副教授 硕导

谢枫2017年毕业于浙江大学并获博士学位，入选国家博新人才，姑苏创新创业领军人才，苏州大学优秀青年学者。谢枫博士致力于研究蛋白翻译后修饰、细胞信号转导及外泌体在肿瘤转移和肿瘤免疫中的分子机制以及治疗策略的研发。个人主页: https://web.suda.edu.cn/xiefeng/. 邮箱: [email protected].

张正奎 特聘副教授

张正奎于2018年毕业于浙江大学生命科学研究院并获得细胞生物学博士学位。2018-2020年加入周芳芳教授课题组任职博士后。2020-2022年在荷兰国家癌症研究所任职博士后。2022年12月加入周芳芳教授课题组受聘为苏州大学特聘副教授。

褚峰 助理研究员

褚峰于2014年获得苏州大学发育生物学专业硕士学位，同年加入苏州大学周芳芳教授课题组担任技术员职位。

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E-mail: [email protected]