Endemic fluorosis is one of the serious endemic diseases in China. In order to effectively prevent and control the development and prevalence of endemic fluorosis, the former National Health and Family Planning Commission, the National Development and Reform Commission, and the Ministry of Finance formulated the "Thirteenth Five-Year National Plan on Endemic Diseases Prevention and Control" (2016-2020), and called on all local authorities to enforce endemic disease prevention and control measures in accordance with the law, to steadily promote the control and elimination of endemic fluorosis, and to consolidate the achievements of prevention and control work. Based on the latest literature, this paper summarized efforts of endemic fluorosis prevention and control in China since the Thirteenth Five-Year Plan was promulgated, including drinking-water fluorosis areas (such as Tianjin, Fujian, Shanxi, Jilin, Gansu, Liaoning, Qinghai, Shandong, Henan, etc.), coal-burning fluorosis areas (such as Guizhou, Shaanxi, Yunnan, Hubei, etc.), and drinking-tea fluorosis areas (such as Tibet, Sichuan, Qinghai, Inner Mongolia, Ningxia, Xinjiang, Gansu, etc.). The prevention and control of drinking-water fluorosis in China has achieved remarkable results:in most of the fluorosis areas the water defluorination rate is more than 90%; in coal-burning fluorosis areas the stove improvement rate is mostly more than 90%; in most drinking-tea fluorosis areas the fluoride levels of brick tea are still higher than the national tea fluoride standard, indicating a high fluoride exposure level. A screening of children aged 8-12 years with dental fluorosis found that the prevalence of drinking water-type disease areas was quite different. Among them, the provinces with prevalence < 8% were Fujian and Liaoning Province; the provinces close to the control standard (30%) were Shanxi, Jilin, Qinghai, and Shandong Province; Tianjin, Gansu and Henan Province that did not meet the control standards. The prevalence of dental fluorosis in the coal-burning fluorosis area and the drinking-tea fluorosis area had reached the control standard, which may be related to the fact that local children consume less smoked spicy and drink less tea. Progress have been made in the prevention and control of endemic fluorosis in China, but some endemic areas have not met the control or elimination standards. The results suggest continuing targeted prevention and control of endemic fluorosis in accordance with law.