ORIGINAL RESEARCH article
Front. Oncol., 01 June 2022Sec. Pharmacology of Anti-Cancer Drugs
Volume 12 - 2022 |
https://doi.org/10.3389/fonc.2022.913670
CD3D Is an Independent Prognostic Factor and Correlates With Immune Infiltration in Gastric Cancer Li Yuan1,2,3†,  Jingli Xu4†,  Yunfu Shi4,  Zhiyuan Jin1, Zhehan Bao4, Pengcheng Yu4, Yi Wang4, Yuhang Xia4,  Jiangjiang Qin1,2,3*,  Bo Zhang5* and  Qinghua Yao5,6,7*1The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, China2Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer, Zhejiang Cancer Hospital, Hangzhou, China3Zhejiang Key Laboratory of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer, Zhejiang Cancer Hospital, Hangzhou, China4First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China5Department of Integrated Chinese and Western Medicine, Institute of Basic Medicine and Cancer (IBMC), The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Chinese Academy of Sciences, Hangzhou, China6Key Laboratory of Traditional Chinese Medicine Oncology, Zhejiang Cancer Hospital, Hangzhou, China7Key Laboratory of Head and Neck Cancer Translational Research of Zhejiang Province, Hangzhou, ChinaThe protein encoded by CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. Previous studies have shown that CD3D is associated with prognosis and treatment response in breast, colorectal, and liver cancer. However, the expression and clinical significance of CD3D in gastric cancer are not clear. In this study, we collected 488 gastric cancer tissues and 430 paired adjacent tissues to perform tissue microarrays (TMAs). Then, immunohistochemical staining of CD3D, CD3, CD4, CD8 and PD-L1 was conducted to investigate the expression of CD3D in gastric cancer and the correlation between the expression of CD3D and tumor infiltrating lymphocytes (TILs) and PD-L1. The results showed that CD3D was highly expressed in gastric cancer tissues compared with paracancerous tissues (P |