彭 鹏 |
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彭鹏教授 博士,博士生导师
通讯地址:山东省青岛市滨海公路72号山东大学青岛校区K6-226 联系电话: 0532-58631456 电子邮箱: [email protected]
教育经历 2006.9 – 2011.7 北京大学药学院 天然药物及仿生药物国家重点实验室 (导师:叶新山 教授) 化学生物学博士 2002.9 – 2006.7 兰州大学化学与化工学院 化学基地班 (论文指导老师为 曹小平教授) 理学学士 工作经历 2016.6 – 今 山东大学国家糖工程技术研究中心研究员,未来计划学者,齐鲁青年教授 2014.2 – 2016.5 Konstanz大学化学系博士后研究员(合作导师:Richard R.Schmidt教授) 2012.8 - 2014.2 香港大学化学系 博士后研究助理(合作导师:李学臣教授) 研究方向与兴趣 新的寡糖化学合成方法的发展。 生物活性寡糖(肿瘤,病毒,细菌相关糖抗原)的合成及药物活性评价。 以糖类化合物为基础的抗菌、抗癌疫苗的研制(设计,合成及评价)。 科研项目 1. 肌营养不良蛋白聚糖Core M3型甘露糖肽的精确制备及功能探索,国家自然科学基金“生物大分子动态修饰与化学干预”重大研究计划培育项目(92053110)2021.1 − 2023.12(主持) 2.格氏乳球菌源脂磷壁酸衍生物的化学合成研究及免疫活性评价,国家自然科学基金面上项目(21977063)2020.1 − 2023.12(主持) 3. HNK-1抗原相关寡糖的合成及构效关系研究,国家自然科学基金青年项目(21702125)2018.1 − 2020.12(主持) 4.乳糖胺糖基模块高效制备及其在两种具有重要生物活性的寡糖合成中的应用,山东省自然科学基金(ZR2017BB045)2017.9 − 2019.12(主持) 5.流感病毒血凝素受体相关寡糖的合成及其在抗病毒药物研发中的应用,山东省重点研发计划(GG201809110268)2019.1 − 2020.12(主持) 6.基于成药性特征的微生物天然产物合成生物学创新,国家重点研发计划(2018YFA0902000)2019.7 − 2024.6(参与) 代表性论文 1. Tianlu Li*, Tong Li, Yajing Sun, Yue Yang, Papan Lv, Fengshan Wang, Houxiang Lou, Richard R. Schmidt*,Peng Peng* Regioselective benzoylation of unprotected β-glycopyranosides with benzoyl cyanide and an amine catalyst – application to saponin synthesisOrg. Chem. Front.2021,8,260-265. 2. Tianlu Li+, Tong Li+, Michael Linseis+, Fengshan Wang, Rainer F. Winter, Richard R. Schmidt*, Peng Peng* Catalytic Regioselective Benzoylation of 1,2-trans-Diols in Carbohydrates with Benzoyl Cyanide: The Axial Oxy Group Effect and the Action of Achiral and Chiral Amine Catalysts.ACS Catal.2020,10, 11406-11416. 3. Tong Li+, Tianlu Li+, Tongxiao Cui, Yajing Sun, Fengshan Wang, Hongzhi Cao, Richard R. Schmidt*,Peng Peng* Regioselective One-Pot Benzoylation of Triol and Tetraol Arrays in Carbohydrates.Org. Lett.2018,20, 3862-3865. 4.Peng Peng, Richard R. Schmidt* Acid–Base Catalysis in Glycosidations: A Nature Derived Alternative to the Generally Employed Methodology.Acc. Chem. Res.2017,50, 1171-1183. 5.Peng Peng, Michael Linseis, Rainer F. Winter, Richard R. Schmidt* Regioselective Acylation of Diols and Triols: The Cyanide EffectJ. Am. Chem. Soc.2016,138, 6002-6009. 6.Peng Peng, Richard R. Schmidt* An Alternative Reaction Course inO-glycosidation withO-glycosyl Trichloroacetimidates as Glycosyl Donors and Lewis Acidic Metal Salts as Catalyst: Acid-Base Catalysis with Gold Chloride-Glycosyl Acceptor AdductsJ. Am. Chem. Soc.2015,137, 12653-12659. 7.Peng Peng, Yiqun Geng, Göttker-Schnetmann, Inigo and Richard R. Schmidt* 2-Nitro-thioglycosides: α- and β-Selective Generation and Their Potential as β-Selective Glycosyl DonorsOrg. Lett.2015,17, 1421-1424. 8.Peng Peng+, Han Liu+, Jianzhi Gong, John M. Nicholls, Xuechen Li*A Facile Synthesis of Sialylated Oligolactosamine Glycans from Lactose via the Lafont IntermediateChem.Sci.2014,5, 3634-3639. 9.Peng Peng, De-Cai Xiong, Xin-Shan Ye*Ortho-Methylphenylthioglycosides as Glycosyl Building Blocks for Preactivation-based Oligosaccharide SynthesisCarbohydr.Res.2014,384, 1-8. 10.Peng Peng, Xin-Shan Ye*O,O-Dimethylthiophosphonosulfenyl Bromide-silver Triflate: a New Powerful Promoter System for the Preactivation of ThioglycosidesOrg. Biomol. Chem.2011,9, 616-622. 11. Yinping Li, Weiying Hong, Henan Zhang, Tiantian Zhang, Zhiyong Chen, Shiling Yuan,Peng Peng,*Min Xiao,*Li Xu*Photothermally triggered cytosolic drug delivery of glucose functionalized polydopamine nanoparticles in response to tumor microenvironment for the GLUT1-targeting chemo-phototherapy.J. Control. Release2020, 317, 232-245. 12. Wei Song+, Yong Sun+, Lintao Xu, Yajing Sun, Tianlu Li,Peng Peng,*Hongxiang Lou* Synthesis of nature product kinsenoside analogues with anti-inflammatory activityBioorg. Med. Chem.2021,29, 115854. |
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