性    别： 男    

职    称： 教授

导    师： 博士生导师、硕士生导师

学科专业： 干细胞与再生医学

    个人简介：

      张宏波，中山大学中山医学院教授、博士生导师，国家级人才工程青年项目入选者，广东省青年珠江学者、中山大学引进青年杰出人才。2016年毕业于瑞士联邦理工大学（EPFL），师从代谢领域权威Johan Auwerx 教授获得博士学位，2017年中山大学“百人计划”项目引进。其研究工作首次揭示干细胞衰老的线粒体失衡机制，提出线粒体能量代谢在调节骨骼肌干细胞衰老中的重要作用，并发现NAD+依赖的延缓成体干细胞衰老和防治骨骼肌营养不良疾病的小分子代谢干预方法。相关成果发表于Science、Science Translational Medicine、Nature Reviews Endocrinology、Kidney International等期刊，并获授权国际/国内发明专利3项，软件著作权1项。

      团队综合运用生物信息学、分子细胞生物学等方法研究能量代谢，尤其是线粒体功能对发育过程中细胞命运决定、成体干细胞功能维持和衰老的调节作用。现阶段主要研究方向如下：       1. 成体干细胞衰老的分子机制。干细胞长期被认为具备永生能力，近年的研究发现其会随着个体衰老而衰老，但调节干细胞衰老的分子机制不明。团队以骨骼肌干细胞为模型，研究静息干细胞在正常生理条件下的衰老机制，揭示细胞内源性信号通路的变化、线粒体功能改变、细胞微环境扰动对干细胞，尤其是骨骼肌干细胞衰老的影响，以寻找到延缓干细胞衰老、延长寿命、促进老年健康的有效方法。

      2. 发育过程中的细胞命运决定。发育的本质是细胞在特定时空精确分化的过程，是研究细胞命运决定的理想模型。团队以肢体发育为重点，借助自主开发的单细胞数据分析工具，并结合体内外基因功能验证方法，系统性研究发育过程中细胞命运的歧化过程和和空间位置的确定机制，最终目的在于为再生医学提供方法和技术指引。

      3. 能量代谢和表观遗传对成体干细胞功能的影响。线粒体能量代谢与蛋白质表观遗传修饰存在密切联系，若干代谢物如NAD+、乙酰辅酶A等可以直接作为蛋白质乙酰化、甲基化等修饰的底物。团队关注乙酰化转移酶、去乙酰化酶等对骨骼肌干细胞活化、分化、衰老等细胞功能和行为的影响，为促进骨骼肌再生，防治肌萎缩和肌肉营养不良等疾病提供借鉴。

学术出版物和专利：

第一或通讯作者论文：

*, corresponding authors; #, equal contribution

1     Zhang H#, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D'Amico D, Ropelle ER, Lutolf MP, Aebersold R, Schoonjans K, Menzies KJ* & Auwerx J*. NAD(+) repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 2016 (IF: 56.9，ESI高被引论文).

2     Menzies KJ#, Zhang H#, Katsyuba E & Auwerx J*. Protein acetylation in metabolism - metabolites and cofactors. Nat Rev Endocrinol, 2016 (IF: 40.5).

3     Ryu D#, Zhang H#, Ropelle ER, Sorrentino V, Mazala DA, Mouchiroud L, Marshall PL, Campbell MD, Ali AS, Knowels GM, Bellemin S, Iyer SR, Wang X, Gariani K, Sauve AA, Canto C, Conley KE, Walter L, Lovering RM, Chin ER, Jasmin BJ, Marcinek DJ, Menzies KJ & Auwerx J*. NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Sci transl med, 2016 (IF: 17.1).

4     Peng B, Chen Y, Wang Y, Fu Y, Zeng X, Zhou H, Abulaiti Z, Wang S & Zhang H*. BTG2 acts as an inducer of muscle stem cell senescence. Biochem Biophys Res Commun, 2023 (IF: 3.1).

5     Aging Biomarker C, Bao H, Cao J, Chen M, Chen M, Chen W, Chen X, Chen Y, …, Zhang H*, Zhang L*, Zhang W*, Zhang Y*, Zhang YW*, Zhang Z*, Zhao T*, Zhao Y*, Zhu D*, Zou W*, Pei G* & Liu GH*. Biomarkers of aging. Sci China Life Sci, 2023 (IF: 9.1，封面论文).

6     Addicks GC#, Zhang H#, Ryu D#, Vasam G, Green AE, Marshall PL, Patel S, Kang BE, Kim D, Katsyuba E, Williams EG, Renaud JM, Auwerx J* & Menzies KJ*. GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression. J Cell Biol, 2022 (IF: 7.8).

7     Yang H, Guo F, Guo Q, Wang Y, He P, Zhang H* & Wang S*. The clinical value of PlGF and the sFlt1/PlGF ratio in the management of hypertensive pregnancy disorders: A retrospective real-world study in China. Clin Chim Acta, 2022 (IF: 5.0).

8     Chen Y, Zhang B, Liu T, Chen X, Wang Y* & Zhang H*. T Cells With Activated STAT4 Drive the High-Risk Rejection State to Renal Allograft Failure After Kidney Transplantation. Front Immunol, 2022 (IF: 7.3).

9     Guo F, Zhang B, Yang H, Fu Y, Wang Y, Huang J, Cheng M, Li X, Shen Z, Li L, He P, Xiang AP, Wang S* & Zhang H*. Systemic transcriptome comparison between early- And late-onset pre-eclampsia shows distinct pathology and novel biomarkers. Cell Prolif, 2021 (IF: 8.5).

10   Wang S, Zhang B, Addicks GC, Zhang H, Menzies KJ* & Zhang H*. Muscle Stem Cell Immunostaining. Curr Protoc Mouse Biol, 2018 (专著).

11   Addicks GC, Marshall P, Jasmin BJ, Renaud JM, Zhang H* & Menzies KJ*. Critical Assessment of the mdx Mouse with Ex Vivo Eccentric Contraction of the Diaphragm Muscle. Curr Protoc Mouse Biol, 2018 (专著).

12   Zhang H#, Menzies KJ & Auwerx J*. The role of mitochondria in stem cell fate and aging. Development, 2018 (IF: 4.6，ESI高被引论文).

13   Spichtig D#, Zhang H#, Mohebbi N, Pavik I, Petzold K, Stange G, Saleh L, Edenhofer I, Segerer S, Biber J, Jaeger P, Serra AL* & Wagner CA*. Renal expression of FGF23 and peripheral resistance to elevated FGF23 in rodent models of polycystic kidney disease. Kidney int, 2014 (IF: 19.6).

其他论文：

1     Liu T, Chen X, Peng B, Liang C, Zhang H & Wang S. A novel prognostic model based on immunogenic cell death-related genes for improved risk stratification in hepatocellular carcinoma patients. J Cancer Res Clin Oncol, 2023 (IF: 3.1).

2     Lai BQ, Wu RJ, Han WT, Bai YR, Liu JL, Yu HY, Yang SB, Wang LJ, Ren JL, Ding Y, Li G, Zeng X, Ma YH, Quan Q, Xing LY, Jiang B, Wang YQ, Zhang L, Chen ZH, Zhang HB, Chen YF, Zheng QJ & Zeng YS. Tail nerve electrical stimulation promoted the efficiency of transplanted spinal cord-like tissue as a neuronal relay to repair the motor function of rats with transected spinal cord injury. Biomaterials, 2023 (IF: 14).

3     Lai BQ, Bai YR, Han WT, Zhang B, Liu S, Sun JH, Liu JL, Li G, Zeng X, Ding Y, Ma YH, Zhang L, Chen ZH, Wang J, Xiong Y, Wu JH, Quan Q, Xing LY, Zhang HB & Zeng YS. Construction of a niche-specific spinal white matter-like tissue to promote directional axon regeneration and myelination for rat spinal cord injury repair. Bioact Mater, 2022 (IF: 18.9).

4     Romani M, Sorrentino V, Oh CM, Li H, de Lima TI, Zhang H, Shong M & Auwerx J. NAD(+) boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle. Cell reports, 2021 (IF: 8.8).

5     Muus C, Luecken MD, Eraslan G, Sikkema L, Waghray A, Heimberg G, Kobayashi Y, Vaishnav ED, …, Consortium NL & Human Cell Atlas Lung Biological N. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nat Med, 2021 (IF: 82.9， ESI高被引论文).

6     Li G, Zhang B, Sun JH, Shi LY, Huang MY, Huang LJ, Lin ZJ, Lin QY, Lai BQ, Ma YH, Jiang B, Ding Y, Zhang HB, Li MX, Zhu P, Wang YQ, Zeng X & Zeng YS. An NT-3-releasing bioscaffold supports the formation of TrkC-modified neural stem cell-derived neural network tissue with efficacy in repairing spinal cord injury. Bioact Mater, 2021 (IF: 18.9).

7     Sungnak W, Huang N, Becavin C, Berg M, Queen R, Litvinukova M, Talavera-Lopez C, Maatz H, Reichart D, Sampaziotis F, Worlock KB, Yoshida M, Barnes JL & Network HCALB. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med, 2020 (IF: 82.9，ESI高被引论文).

8     Litvinukova M, Talavera-Lopez C, Maatz H, Reichart D, Worth CL, Lindberg EL, Kanda M, Polanski K, Heinig M, Lee M, Nadelmann ER, Roberts K, Tuck L, Fasouli ES, DeLaughter DM, McDonough B, Wakimoto H, Gorham JM, Samari S, Mahbubani KT, Saeb-Parsy K, Patone G, Boyle JJ, Zhang H, Zhang H, Viveiros A, Oudit GY, Bayraktar OA, Seidman JG, Seidman CE, Noseda M, Hubner N & Teichmann SA. Cells of the adult human heart. Nature, 2020 (IF: 64.8，ESI高被引论文).

9     Chen YP, Yin JH, Li WF, Li HJ, Chen DP, Zhang CJ, Lv JW, Wang YQ, Li XM, Li JY, Zhang PP, Li YQ, He QM, Yang XJ, Lei Y, Tang LL, Zhou GQ, Mao YP, Wei C, Xiong KX, Zhang HB, Zhu SD, Hou Y, Sun Y, Dean M, Amit I, Wu K, Kuang DM, Li GB, Liu N & Ma J. Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma. Cell Res, 2020 (IF: 44.1).

10   Zhu X, Shen W, Yao K, Wang H, Liu B, Li T, Song L, Diao D, Mao G, Huang P, Li C, Zhang H, Zou Y, Qiu Y, Zhao Y, Wang W, Yang Y, Hu Z, Auwerx J, Loscalzo J, Zhou Y & Ju Z. Fine-Tuning of PGC1alpha Expression Regulates Cardiac Function and Longevity. Circ Res, 2019 (IF: 20.1).

11   Lahiri S, Kim H, Garcia-Perez I, Reza MM, Martin KA, Kundu P, Cox LM, Selkrig J, Posma JM, Zhang H, Padmanabhan P, Moret C, Gulyas B, Blaser MJ, Auwerx J, Holmes E, Nicholson J, Wahli W & Pettersson S. The gut microbiota influences skeletal muscle mass and function in mice. Sci transl med, 2019 (IF: 17.1，ESI高被引论文).

12   Li H, Wang X, Rukina D, Huang Q, Lin T, Sorrentino V, Zhang H, Bou Sleiman M, Arends D, McDaid A, Luan P, Ziari N, Velazquez-Villegas LA, Gariani K, Kutalik Z, Schoonjans K, Radcliffe RA, Prins P, Morgenthaler S, Williams RW & Auwerx J. An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function. Cell Syst, 2018 (IF: 9.3).

13   Sorrentino V, Romani M, Mouchiroud L, Beck JS, Zhang H, D'Amico D, Moullan N, Potenza F, Schmid AW, Rietsch S, Counts SE & Auwerx J. Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity. Nature, 2017 (IF: 64.8，ESI高被引论文).

14   Gariani K, Ryu D, Menzies KJ, Yi HS, Stein S, Zhang H, Perino A, Lemos V, Katsyuba E, Jha P, Vijgen S, Rubbia-Brandt L, Kim YK, Kim JT, Kim KS, Shong M, Schoonjans K & Auwerx J. Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease. J hepat, 2017 (IF: 25.7).

15   Rabhi N, Denechaud PD, Gromada X, Hannou SA, Zhang H, Rashid T, Salas E, Durand E, Sand O, Bonnefond A, Yengo L, Chavey C, Bonner C, Kerr-Conte J, Abderrahmani A, Auwerx J, Fajas L, Froguel P & Annicotte JS. KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response. Cell rep, 2016 (IF: 8.8).

16   Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku CS, Koo SI, Fomitchova A, Canto C, Schoonjans K, Sauve AA, Lee JY & Auwerx J. Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. Hepatology, 2016 (IF: 13.5，ESI高被引论文).

17   Ryu D, Jo YS, Lo Sasso G, Stein S, Zhang H, Perino A, Lee JU, Zeviani M, Romand R, Hottiger MO, Schoonjans K & Auwerx J. A SIRT7-dependent acetylation switch of GABPbeta1 controls mitochondrial function. Cell metab, 2014 (IF: 29.0).

18   Pirinen E, Canto C, Jo YS, Morato L, Zhang H, Menzies KJ, Williams EG, Mouchiroud L, Moullan N, Hagberg C, Li W, Timmers S, Imhof R, Verbeek J, Pujol A, van Loon B, Viscomi C, Zeviani M, Schrauwen P, Sauve AA, Schoonjans K & Auwerx J. Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle. Cell metab, 2014 (IF: 29.0).

专利和软著：

1   Zhang, H., Menzies, K. J., Auwerx, J. Ryu, D. Agents and methods using thereof for the prevention and treatment of stem cells senescence. 已授权PTC专利, WO2017042198, (2017).  2   Zhang, H., Menzies, K. J., Auwerx, J. Ryu, D. Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders. 已授权PTC专利, WO2017042196, (2017). 3  张宏波，王帅玉，张宝，杨浩. 胎盘相关疾病标志物的筛选方法及标志物. 已授权中国发明专利, ZL 2020 1 0908665.8, (2023). 4  张宏波，张宝，王帅玉. 基因拟时序表达分析Python包软件[简称：PLOGS软件]. 已授权软件著作权，5091728，(2020).

获奖及荣誉：

2020  国家级人才工程青年项目； 2018  广东省青年“珠江学者”； 2016  瑞士青年科学家奖（Swiss Young Investigator Award）； 2016  The Lausanne Integrative Metabolism and Nutrition Alliance travel grant; 2014  CARIGEST  干细胞研究奖（fellowship award for stem cell research）

招生招聘信息：

      欢迎有志于从事生命科学，尤其是发育和干细胞衰老研究的博士后和专职科研人员加入团队，也热情欢迎联系攻读实验室硕博士研究生和开展本科毕业设计（招生专业：干细胞与再生医学）。团队研究经费充足，氛围和谐，提供宽松科研环境支持有兴趣、有热情的研究者进行自由的前沿探索。申请者可通过发邮件至[email protected]联系。