原标题：一款简单经济的小型气溶胶发生器--BGI Collison Nebulizer 实验室小型气溶胶发生器

对于实验室的兄弟姐妹来说，通常没有大手笔来来购买大型的顶尖的仪器设备。那些大型设备货值高，价格贵，维护也和麻烦，需要占用太多的实验室资源。

膜法空间今天给大家介绍一种小型研究型气溶胶粒子发生器0.05 µm to 20 µm。

BGI MRE型/NSF型Collison喷雾器

Collison Nebulizer

技术特性：

典型应用领域：

很久以来美国BGI公司研制的Collison喷雾器都被公认为将各种液体气溶胶化的最有效技术。Collison喷雾器包括许多不同配置的喷雾器，经过了广泛的性能测试以确保满足不同用户的具体要求。

之前已被证实：3喷嘴喷雾器产生相同的质量中值直径(MMD)、所需的气流和液体发生速率仅是6喷嘴喷雾器的一半。同样，短款的喷雾器能够产生与标准高度喷雾器一样的质量中值直径(MMD)。

经改良的MRE型Collison喷雾器是由英国波顿的Microbiological Research Establishment设计的平底型喷雾器，有3喷嘴和6喷嘴两种。所有的金属部件都是由316不锈钢加工而来。BGI喷雾器顶部的”T”形杆既提供了空气进口，又连接了压力表，这是BGI的创新，便于直接进行气压测试。

NSF Collison喷雾器是BGI公司为满足美国全国卫生基金会（National Sanitation Foundation，NSF）的要求、在MRE型基础上特别设计的短款。NSF进行生物危害测试时，安全柜内有限的空间需要更短的配置。该款产品型号是CN31I，已广泛用于的孢子测试，配有六个喷嘴头，黄铜镀镍加工。它是NSF自用并推荐的测试生物安全柜人员安全性和受试样品安全性的喷雾器。

过去的二、三十年里，BGI接到不少请求生产更多喷嘴数的喷雾器，曾经24喷嘴Collison喷雾器是一种定制型号，现在标准化的24喷嘴Collison喷雾器是6喷嘴MRE改良型的扩大版。它有一个32盎司，干净覆膜的瓶子，以保持和3喷嘴、6喷射喷雾器相同的墙板间距尺寸。因此，新的产品能够输出4倍于6喷嘴相同特性的气溶胶，但MAX压力限制为30 PSIG。

BGI Collison Nebulizer

Collison Nebulizers (1, 3, 6, 24 and NSF Collisons) The Collison Nebulizer has long been the recognized technique for the efficient aerosolization of various liquids. Mesa manufactures a comprehensive variety of nebulizers, all of which have undergone exhaustive performance tests.1, 3 or 6 Jet Collison NebulizerAll Mesa Collison Nebulizers have all the metal components fabricated from 316 stainless steel. All O-rings are Buna-N or silicone rubber. Glass jars are either Crown Glass (standard) or Pyrex (precious fluids jar only). The 24 jet Collison jar is coated with clear PVC.

Applications

• Aerobiology

• Aerosol Research

• Biohazard Enclosure Testing

• Filter Evaluation

This describes a numerical analysis of the Collison nebulizer to determine the total number of droplets produced for a given back pressure and the count within 2 standard deviations of the mean droplet size (assuming a log-normal distribution). The Collison nebulizer can be operated with a variety of “jet” numbers depending on the attachment. Each jet requires approximately 2 Lpm of air and produces droplets with an MMAD of 2.5 µm with a GSD of 1.8. The comparable CMAD is 0.89 µm. As given in the table below, the amount of liquid in the nebulizer reservoir used per hour per jet varies depending on the backpressure applied to the nebulizer which can be computed with the following equation: To determine the number of droplets produced per jet per hour by the Collison, a resulting log-normal distribution of droplet sizes was assumed. The central concept used to determine the number of droplets produced by the Collison is that the liquid volume contained in the total of all droplets produced must be equal to the volume of liquid produced by the Collison on a per time basis. A spreadsheet was constructed with 600 diameters ranging from 0.05 µm to 20 µm in even increments on a log-basis (-3 to 3 by every 0.01 ln values). The frequency of occurrence of each diameter was computed with the use of the probability distribution function for a log-normal distribution. The volume associated with each diameter was computed using the equation for the volumeof a sphere. The “Solver” function in Excel was then used to determine the counts for each diameter that caused the sum of all volumes (for each diameter) to be equal to the volume generated per hour (as per the equation above) while weighting the count for each diameter by their computed frequency of occurrence. From the total number, the count between +/- 2 standard deviations of the mean was calculated. The results given in the table below were converted to a per minute basisand include the liquid output for a single jet as well as the estimated counts for a single, 3, 6, and 24 jet Collison.

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