杨劲松 教授(博士生导师) |
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杨劲松教授(博士生导师) 单位:四川大学华西药学院天然药物学系 通信地址:成都市人民南路三段17号四川大学华西药学院(610041) E-mail:[email protected], [email protected] 学习和研究工作简历 杨劲松教授,四川大学化学专业学士(1992年)、南开大学有机化学理学硕士(1995年)、华西医科大学药物化学理学博士(1998年),日本东邦大学药学部药物化学博士后(1998年12月-1999年12月)。从1998年9月至今,在四川大学任教,历任助教、讲师、副教授,现为华西药学院教授、博士生导师、天然药物学系主任,中国化学会糖化学专业委员会委员。主要从事寡糖的化学合成和生物活性研究。在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Org. Lett.、J. Org. Chem.等学术期刊上发表论文30余篇。近5年主持国家自然科学基金面上项目3项;参加国家基金委创新群体、科技部十二五重大新药创制专项各1项。 获得的学术奖励 首届中国化学会糖化学贡献奖(2021)、Asian Core Program Lectureship Award (2018)、第五届“阿达玛斯”学术论文奖优秀奖(2018)、教育部新世纪优秀人才(2008)和四川省杰出青年基金(2008)。 研究兴趣: • 新的糖化学合成方法和策略的发展 • 细菌细胞壁糖缀合物、肿瘤相关糖抗原的合成和活性评价 • 基于糖类的新药发现 近期发表论文 1. Xing-Ling Pan, Lei Huang, Yan Zeng, Chun-Yun Xu, Dong-Mei Liu, Yue Chu, Yong Qin, Jin-Song Yang*. Synthesis of an Unusual Hexasaccharide Repeating Unit from the Cell Wall Polysaccharide of Eubacterium saburreum strain T19, Org. Chem. Front., 2020, 7, 2298. 2. Dong-Mei Liu, Hong-Ling Wang, Jin-Cai Lei, Xian-Yang Zhou, Jin-Song Yang*. A Highly α-Stereoselective Sialylation Method Using 4-O-4-Nitropicoloyl Thiosialoside Donor, Eur. J. Org. Chem. 2020, 575. 3. Yan Zeng and Jin-Song Yang*. Stereoselective Synthesis of a Tetrasaccharide Fragment from Cellulosome Produced by Clostridium thermocellum, Asian J. Org. Chem. 2020, 9, 317. 4. Jin-Cai Lei, Yu-Xiong Ruan, Sheng Luo, Jin-Song Yang*. Stereodirecting Effect of C3-Ester Groups on the Glycosylation Stereochemistry of L-Rhamnopyranose Thioglycoside Donors: Stereoselective Synthesis of α- and -L-Rhamnopyranosides, Eur. J. Org. Chem. 2019, 6377. 5. Xian-Yang Zhou, Pan Yang, Sheng Luo, and Jin-Song Yang*. Divergent Synthesis of 3-Deoxy-D-manno-oct-2-ulosonic Acid (Kdo) Glycosides Containing α-(2→4)-Linked Kdo-Kdo Unit, Chem. Asian J. 2019, 14, 454. 6. Wei Huang, Ying-Yu Zhou, Xing-Ling Pan, Xian-Yang Zhou, Jin-Cai Lei, Dong-Mei Liu, Yue Chu, Jin-Song Yang*. Stereodirecting Effect of C5-Carboxylate Substituents on the Glycosylation Stereochemistry of 3‑Deoxy-D-manno-oct-2-ulosonic Acid (Kdo) Thioglycoside Donors: Stereoselective Synthesis of α- and β‑Kdo Glycosides, J. Am. Chem. Soc. 2018, 140, 3574. 7. Yuan Xu, Hua-Chao Bin, Fu Su, Jin-Song Yang*. Stereoselective synthesis of aryl 1,2-cis-furanosides and its application to the synthesis of the carbohydrate portion of antibiotic hygromycin A, Tetrahedron Lett. 2017, 58, 1548. 8. Peng-Cheng Gao, San-Yong Zhu, Hui Cao, Jin-Song Yang*. Total Synthesis of Marine Glycosphingolipid Vesparioside B, J. Am. Chem. Soc. 2016, 138, 1684. 9. Kai Zhu, Jin-Song Yang*. Synthesis of tri- and tetrasaccharide glycosides of (4S)-4-hydroxy-D-proline relevant to the cell wall O-glycans of green alga Chlamydomonas reinhardtii, Tetrahedron 2016, 72, 3113. 10. Jia-Sheng Huang, Wei Huang, Xue Meng, Xin Wang, Peng-Cheng Gao, Jin-Song Yang*. Stereoselective Synthesis of α-3-Deoxy-D-manno-oct-2-ulosonic Acid (α-Kdo) Glycosides Using 5,7-O-Di-tert-butylsilylene-Protected Kdo Ethyl Thioglycoside Donors, Angew. Chem. Int. Ed. 2015, 54, 10894. 11. Shuai Wang, Xue Meng, Wei Huang, Jin-Song Yang*. Study on the Influence of Silyl Protections on the Anomeric Reactivity of Galactofuranosyl Thioglycosides and Application of the Silylated Thiogalactofuranosides to One-Pot Synthesis of Diverse β-D-Oligogalactofuranosides, J. Org. Chem. 2014, 79, 10203. 12. San-Yong Zhu, Jia-Sheng Huang, Shan-Shan Zheng, Kai Zhu, Jin-Song Yang*. First Total Synthesis of the Proposed Structure of Batatin VI, Org. Lett. 2013, 15, 4154. 13. Qiang-Wei Liu, Hua-Chao Bin, Jin-Song Yang*. β-Arabinofuranosylation Using 5-O-(2-Quinolinecarbonyl) Substituted Ethyl Thioglycoside Donors, Org. Lett. 2013, 15, 3974. 14. Xing-Yong Liang, Hua-Chao Bin, Jin-Song Yang*. Tuning Effect of Silyl Protecting Groups on the Glycosylation Reactivity of Arabinofuranosyl Thioglycoside, Org. Lett. 2013, 15, 2834. 15. Xing-Yong Liang, Qiang-Wei Liu, Hua-Chao Bin, Jin-Song Yang*. One-Pot Synthsis of Branched Oligosaccharide by Use of Galacto- and Mannopyranosyl Thioglycoside Diols as Key Glycosylating Agent, Org. Biomol. Chem. 2013, 11, 3903. 16. Xing-Yong Liang, Li-Ming Deng, Jin-Song Yang*. Review on Synthesis and Occurrence of Oligoaranbino-, Oligogalacto- and Oligofructo furanoses, Chin. J. Org. Chem. 2013, 33, 245. 17. Jia Shao, Jin-Song Yang*. A Diastereoselective Cyclic Imine Cycloaddition Strategy to Access Polyhydroxylated Indolizidine Skeleton: Concise Syntheses of (+)-/(–)-Lentiginosines and (–)-2-epi-Steviamine, J. Org. Chem. 2012, 77, 7891. 18. San-Yong Zhu, Jin-Song Yang*. Synthesis of Tetra- and Hexasaccharide Fragments Corresponding to the O-Antigenic Polysaccharide of Klebsiella Pneumoniae, Tetrahedron 2012, 68, 3795. 19. Li-Min Deng, Xia Liu, Xing-Yong Liang, Jin-Song Yang*. Regioselective Glycosylation Method Using Partially Protected Arabino- and Galactofuranosyl Thioglycosides as Key Glycosylating Substrates and Its Application to One-Pot Synthesis of Oligofuranoses, J. Org. Chem. 2012, 77, 3025. 20. Lin Xie, San-Yong Zhu, Xiao-Qiu Shen, Li-Li He, Jin-Song Yang*. Total Synthesis of Batatoside L, J. Org. Chem. 2010, 75, 5764. 21. Xing-Yong Liang, Li-Min Deng, Xia Liu, Jin-Song Yang*. Efficient One-pot Syntheses of α-D-Arabinofuranosyl Tri- and Tetrasaccharides Present in Cell Wall Polysaccharide of Mycobacterium Tuberculosis, Tetrahedron 2010, 66, 87. 22. Xiao-Qiu Shen, Lin Xie, Liang Gao, Li-Li He, Qian Yang, Jin-Song Yang*. Synthetic Studies on the Trisaccharide Intermediate of Resin Glycoside Merremoside H2, Carbohydr. Res. 2009, 344, 2063. 23. Ming Lei, Liang Gao, Jin-Song Yang*. Microwave-assisted Palladium-catalyzed Cross-coupling Reactions between Pyranoid Glycals and Aryl Bromides. Synthesis of 20-Deoxy C-Aryl-β-glycopyranosides, Tetrahedron Lett. 2009, 50, 5135. 24. Qian Yang; Ming Lei; Qin-Jian Yin; Jin-Song Yang*. Silver(I) oxide-mediated Regioselective 2-Monoacylation in 3-O-Benzyl-α-L-rhamnopyranosides and Application in Synthesis of a Protected Tetrasaccharide Fragment of Potent Cytotoxic Saponins Gleditsiosides C and D, Carbohydr. Res. 2007, 342, 1175. 25. Qiang Tian, Xing-Mei Zhu, Jin-Song Yang*. Amberlyst 15-Catalyzed Efficient Synthesis of 2,3-Unsaturated Glycosides via Ferrier Rearrangement for Glycal. Synth. Commun. 2007, 37, 691. 26. Qiang Tian, Shuo Zhang, Qian Yu, Mei-Bo He; Jin-Song Yang*. Amberlyst 15 as a Mild and Effective Activator for the Glycosylation with Disarmed Glycosyl Trichloroacetimidate Donors. Tetrahedron 2007, 63, 2142. 27. Xing-Mei Zhu, Li-Li He, Guang-Li Yang, Ming Lei, Si-Shi Chen, Jin-Song Yang*. Syntheses of the Macrolide Subunits of Merremoside-type Resin Glycosides. Synlett 2006, 3510. 28. Qian Yang, Xing Mei Zhu, Jin Song Yang*. Silver(I) Oxide Mediated Regioselective Monoacylation of 2,4-Dihydroxyls in L-Rhamnopyranosides. Chin. Chem. Lett. 2006, 17, 1009. |
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