吕爱平，讲座教授，上海市中医药研究院关节炎研究所所长、名誉所长，香港浸会大学中医药学院院长

通讯地址：香港九龙塘，香港浸会大学中医药学院

Aiping Lv, Chair professor,

Honorary Director of Arthritis Research Institute, Shanghai Academy of Traditional Chinese Medicine; The Dean of School of Chinese Medicine, Hong Kong Baptist University

Address: School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong

学习和工作经历

2014.12起 上海中医药大学教授、中西医结合研究院院长（2019）

2012.07–至今 上海市中医药研究院关节炎研究所所长、名誉所长（2020）

2012.02起 香港浸会大学中医药学院院长、Dr. Kennedy Wong 冠名讲座教授

1994.09-1997.07 中国中医研究院获得博士学位

1984.09-1987.07 中国中医研究院获得硕士学位

1978.12-1983.12 江西中医学院获得学士学位

Education and Research experiences

2019-present, Dean, Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine

2014.12-present, Professor, Shanghai University of Traditional Chinese Medicine

2012.02-present, Dean and Dr. Kennedy Wong endowed professor, School of Chinese Medicine, Hong Kong Baptist University

1994.09-1997.07, M.D. China Academy of Traditional Chinese Medicine

1984.09-1987.07, M.M. China Academy of Traditional Chinese Medicine

1978.12-1983.12, M.Bc. Jiangxi University of Traditional Chinese Medicine

研究领域

疾病证候分类与中医临床评价方法研究

骨与关节疾病的新药开发

中药治疗自身免疫性疾病的作用机理

Research area

Classification of Traditional Chinese Medicine syndromes and clinical evaluation strategy of Traditional Chinese Medicine

New drug development for bone and joint diseases

The mechanistic action of Traditional Chinese Medicine in the treatment of autoimmune diseases

研究成果及获奖

获得国家、省市级科研奖励 50项

申报药物相关发明专利95项

Achievements and Awards

Obtained 50 national, provincial and municipal scientific research awards

Declared 95 drug-related invention patents

主要社会兼职

全国政协参政议政人才库首批特聘专家

最高人民检察院特约检查员

第十一届、第十二届全国政协委员

药典委员会委员（名词术语委员会、中医专业委员会）

国际中医药规范化研究协会主席GP-TCM RA 主席

Frontier in Pharmacology杂志副主编

WHO ICD-11 (TM) 专家成员

ISO-TC249中方代表团团长

香港食品卫生局研究委员会成员

香港中医中药发展委员会委员

香港中医药管理委员会委员

香港中药研究与发展委员会委员

澳门科技基金项目顾问

第十一届北京市政协委员

Social positions

The first batch of specially-appointed experts of the CPPCC National People's Political Consultative Conference

Special Inspector of the Supreme People's Procuratorate

The Member of the 11th and 12th National Committee of the Chinese People's Political Consultative Conference

Member of the Pharmacopoeia Committee

Expert member of WHO ICD-11 (TM)

The Head of the Chinese delegation of ISO-TC249

Research Council member of Food and health Bureau, Hong Kong

Member of Hong Kong Chinese Medicine Development Committee

Member of the Hong Kong Chinese Medicine Council

Member of Hong Kong Chinese Medicine Research and Development Committee

Macau Science and Technology Fund Project Consultant

Member of the 11th Beijing CPPCC

基金主持及参与

主持国家自然科学基金、省基金和香港RGC项目累积57项

参与战略规划研究项目17项

2008年国家杰出青年科学基金资助

Grant Funding

Granted over a total of 57 projects from the National Natural Science Foundation of China, Provincial Funds and Hong Kong RGC funds as PI

Participated in 17 national strategic planning research projects

Received the National Science Fund for Distinguished Young Scholars in 2008

代表论文（Publication）

1.ZY Yang, J Dong, ZJ Yang, M Yin, HL Jiang, AP Lu, X Chen, TJ Hou, DS Cao. ChemFLuo: a web-server for structure analysis and identification of fluorescent compounds. Briefings in Bioinformatics (IF=11.6) 2020

2.ZY Yang, ZJ Yang, AP Lu, TJ Hou, DS Cao. Scopy: an integrated negative design python library for desirable HTS/VS database design. Briefings in Bioinformatics(IF=11.6) 2020

3.H Zhao, A Lu, X He. Roles of MicroRNAs in Bone Destruction of Rheumatoid Arthritis. Frontiers in Cell and Developmental Biology (IF=6.7) 8, 1349

4.YQ Deng, H Luo, J Shu, H Shu, C Lu, N Zhao, Y Geng, X He, A Lu. Pien Tze Huang alleviate the joint inflammation in collagen-induced arthritis mice. Chinese Medicine (IF=5.4) 15, 1-9

5.D Fan, C Liu, L Li, C Lu, N Zhao, J Shu, X He, A Lu. Deciphering Antitumor Mechanism of Pien Tze Huang in Mice of Hepatocellular Carcinoma Based on Proteomics. Journal of Immunology Research (IF=4.8) 2020

6.Zhong, L.L.D., Kun, W., Shi, N., Ziea, T.C., Ng, B.F.L., Gao, Y., Bian, Z., Lu, A. Evidence-based Chinese Medicine Clinical Practice Guideline for Stroke in Hong Kong. (2020) Chinese Medicine (United Kingdom) (IF=4.5), 15 (1)

7.Wong, K.H., Xie, Y., Huang, X., Kadota, K., Yao, X.-S., Yu, Y., Chen, X., Lu, A., Yang, Z. Delivering Crocetin across the Blood-Brain Barrier. by Using γ-Cyclodextrin to Treat Alzheimer’s Disease. (2020) Scientific Reports (IF=4.3), 10 (1)

8.Wei, H., Guan, Y.-D., Zhang, L.-X., Liu, S., Lu, A.-P., Cheng, Y., Cao, D.-S. A combinatorial target screening strategy for deorphaning macromolecular targets of natural product. (2020) European Journal of Medicinal Chemistry (IF=6.5), 204.

9.Shi, Y., Shu, H., Wang, X., Zhao, H., Lu, C., Lu, A., He, X. Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid Arthritis. (2020) Frontiers in Pharmacology (IF=5.8), 11.

10.Gao, Y., Wang, K.-X., Wang, P., Li, X., Chen, J.-J., Zhou, B.-Y., Tian, J.-S., Guan, D.-G., Qin, X.-M., Lu, A.-P. A Novel Network Pharmacology Strategy to Decode Mechanism of Lang Chuang Wan in Treating Systemic Lupus Erythematosus. (2020) Frontiers in Pharmacology(IF=5.8), 11

11.Zhao, Y., Zhang, L.-X., Jiang, T., Long, J., Ma, Z.-Y., Lu, A.-P., Cheng, Y., Cao, D.-S. The ups and downs of Poly(ADP-ribose) Polymerase-1 inhibitors in cancer therapy–Current progress and future direction. (2020) European Journal of Medicinal Chemistry (IF=6.5), 203.

12.Ye, W.-L., Shen, C., Xiong, G.-L., Ding, J.-J., Lu, A.-P., Hou, T.-J., Cao, D.-S. Improving docking-based virtual screening ability by integrating multiple energy auxiliary terms from molecular docking scoring. (2020) Journal of Chemical Information and Modeling (IF=4.9), 60 (9), pp. 4216-4230.

13.Chowdhury, D., Wang, C., Lu, A., Zhu, H. Identifying Transcription Factor Combinations to Modulate Circadian Rhythms by Leveraging Virtual Knockouts on Transcription Networks. (2020) iScience (IF=5.1). 23 (9)

14.Gadau, M., Zhang, S.P., Wang, F.C., Liguori, S., Li, W.H., Liu, W.H., Bangrazi, S., Berle, C., Razavy, S., Bian, Z.X., Filomena, P., Hao, Y., Jiang, H.L., Lei, L., Li, T., Zaslawski, C., Liguori, A., Liu, Y.S., Lu, A.P., Tan, Y.S., Yim, W.W., Xie, C.L. A multi-center international study of acupuncture for lateral elbow pain - Results of a randomized controlled trial. (2020) European Journal of Pain (United Kingdom) (IF=3.9), 24 (8), pp. 1458-1470.

15.Wong, K.H., Lu, A., Chen, X., Yang, Z. Natural ingredient-based polymeric nanoparticles for cancer treatment. (2020) Molecules (IF=4.4), 25 (16).

16.Guo, Q., Li, L., Zheng, K., Zheng, G., Shu, H., Shi, Y., Lu, C., Shu, J., Guan, D., Lu, A., He, X. Imperatorin and β-sitosterol have synergistic activities in alleviating collagen-induced arthritis. (2020) Journal of Leukocyte Biology (IF=4.9), 108 (2), pp. 509-517.

17.Wang, K.-X., Gao, Y., Lu, C., Li, Y., Zhou, B.-Y., Qin, X.-M., Du, G.-H., Gao, L., Guan, D.-G., Lu, A.-P. Uncovering the Complexity Mechanism of Different Formulas Treatment for Rheumatoid Arthritis Based on a Novel Network Pharmacology Model. (2020) Frontiers in Pharmacology(IF=5.8), 11.

18.Zhuo, Z., Wan, Y., Guan, D., Ni, S., Wang, L., Zhang, Z., Liu, J., Liang, C., Yu, Y., Lu, A., Zhang, G., Zhang, B.-T. A Loop-Based and AGO-Incorporated Virtual Screening Model Targeting AGO-Mediated miRNA–mRNA Interactions for Drug Discovery to Rescue Bone Phenotype in Genetically Modified Mice. (2020) Advanced Science (IF=16.8), 7 (13)

19.Wu, X., Li, F., Li, Y., Yu, Y., Liang, C., Zhang, B., Zhao, C., Lu, A., Zhang, G. A PD-L1 aptamer selected by loss-gain cell-SELEX conjugated with paclitaxel for treating triple-negative breast cancer (2020) Medical Science Monitor (IF=2.64), 26.

20.Li, L.-F., Wong, T.-L., Zhang, J.-X., Zhou, L.-S., Bai, S.-P., Fung, H.-Y., Cheng, H.-Y., Zhang, Q.-W., Zheng, H.-M., Bao, W.-R., Ma, D.-L., Leung, C.-H., Zhang, G., Bian, Z.-X., Lyu, A.-P., Han, Q.-B. An oligosaccharide-marker approach to quantify specific polysaccharides in herbal formula by LC-qTOF-MS: Danggui Buxue Tang, a case study. (2020) Journal of Pharmaceutical and Biomedical Analysis (IF=3.9), 185.

21.Gong, M., Ye, S., Li, W.-X., Zhang, J., Liu, Y., Zhu, J., Lv, W., Zhang, H., Wang, J., Lu, A., He, K. Regulatory function of praja ring finger ubiquitin ligase 2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells. (2020) American Journal of Physiology - Cell Physiology(IF=4.2), 318 (6), pp. C1123-C1135.

22.Yang, Z.-Y., He, J.-H., Lu, A.-P., Hou, T.-J., Cao, D.-S. Application of negative design to design a more desirable virtual screening library. (2020) Journal of Medicinal Chemistry (IF=7.4), 63 (9), pp. 4411-4429.

23.Yang, Z.-Y., Dong, J., Yang, Z.-J., Lu, A.-P., Hou, T.-J., Cao, D.-S. Structural Analysis and Identification of False Positive Hits in Luciferase-Based Assays. (2020) Journal of chemical information and modeling (IF=4.9), 60 (4), pp. 2031-2043.

24.Yang, Z.-Y., He, J.-H., Lu, A.-P., Hou, T.-J., Cao, D.-S. Frequent hitters: nuisance artifacts in high-throughput screening. (2020) Drug Discovery Today (IF=6.3), 25 (4), pp. 657-667.

25.Chuanxin, Z., Shengzheng, W., Lei, D., Duoli, X., Jin, L., Fuzeng, R., Aiping, L., Ge, Z. Progress in 11β-HSD1 inhibitors for the treatment of metabolic diseases: A comprehensive guide to their chemical structure diversity in drug development. (2020) European Journal of Medicinal Chemistry (IF=6.5), 191

26.Deng, Y., Luo, H., Shu, J., Shu, H., Lu, C., Zhao, N., Geng, Y., He, X., Lu, A. Pien Tze Huang alleviate the joint inflammation in collagen-induced arthritis mice. (2020) Chinese Medicine (United Kingdom) (IF=4.5), 15 (1).

27.Zhang, Y., Zhao, H., Liu, B., Li, L., Zhang, L., Bao, M., Ji, X., He, X., Yi, J., Chen, P., Lu, C., Lu, A. Low Level Antibodies Against Alpha-Tropomyosin Are Associated With Increased Risk of Coronary Heart Disease. (2020) Frontiers in Pharmacology (IF=5.8), 11.

28.Wu, X., Li, F., Dang, L., Liang, C., Lu, A., Zhang, G. RANKL/RANK System-Based Mechanism for Breast Cancer Bone Metastasis and Related Therapeutic Strategies. (2020) Frontiers in Cell and Developmental Biology (IF=6.7), 8.

29.Zhang, X., Tian, R., Lam, W.C., Duan, Y., Liu, F., Zhao, C., Wu, T., Shang, H., Tang, X., Lyu, A., Bian, Z. Standards for reporting interventions in clinical trials of cupping (STRICTOC): Extending the CONSORT statement. (2020) Chinese Medicine (United Kingdom) (IF=4.5), 15 (1)

30.Fu, L., Liu, L., Yang, Z.-J., Li, P., Ding, J.-J., Yun, Y.-H., Lu, A.-P., Hou, T.-J., Cao, D.-S. Systematic Modeling of log D7.4 Based on Ensemble Machine Learning, Group Contribution, and Matched Molecular Pair Analysis. (2020) Journal of Chemical Information and Modeling (IF=4.9), 60 (1), pp. 63-76.

31.Zhao, L., Yang, W., Chen, Y., Huang, F., Lu, L., Lin, C., Huang, T., Ning, Z., Zhai, L., Zhong, L.L.D., Lam, W., Yang, Z., Zhang, X., Cheng, C., Han, L., Qiu, Q., Shang, X., Huang, R., Xiao, H., Ren, Z., Chen, D., Sun, S., El-Nezami, H., Cai, Z., Lu, A., Fang, X., Jia, W., Bian, Z. A Clostridia-rich microbiota enhances bile acid excretion in diarrhea-predominant irritable bowel syndrome. (2020) Journal of Clinical Investigation (IF=14.8), 130 (1), pp. 438-450.

32.Zhang, H., Lu, J., Liu, J., Zhang, G., Lu, A. Advances in the discovery of exosome inhibitors in cancer. (2020) Journal of Enzyme Inhibition and Medicinal Chemistry (IF=5.0), 35 (1), pp. 1322-1330.

33.Zhong, L.L.D., Shi, N., Sun, Y., Ng, B.F.L., Bian, Z., Lu, A. Hong Kong Chinese medicine clinical practice guideline for insomnia. (2020) European Journal of Integrative Medicine (IF=6.5).

34.Yang, S.-Q., Ye, Q., Ding, J.-J., Ming-Zhu, Y., Lu, A.-P., Chen, X., Hou, T.-J., Cao, D.-S. Current advances in ligand‐based target prediction. Wiley Interdisciplinary Reviews: Computational Molecular Science (IF=16.77), e1504

35.Cao, Z., Li, W., Liu, R., Li, C., Song, Y., Liu, G., Chen, Y., Lu, C., Lu, A., Liu, Y. Ph-responsive fluorescence enhanced nanogel for targeted delivery of aur and cddp against breast cancer. (2020) International Journal of Nanomedicine (IF=6.4), 15, pp. 8369-8382.

36.Cui, H., Shu, H., Fan, D., Wang, X., Zhao, N., Lu, C., Lu, A., He, X. Wang-Bi Capsule Alleviates the Joint Inflammation and Bone Destruction in Mice with Collagen-Induced Arthritis. (2020) Evidence-based Complementary and Alternative Medicine (IF=2.6), 2020.

37.Liu, L., Liu, Z., Li, H., Cao, Z., Li, W., Song, Z., Li, X., Lu, A., Lu, C., Liu, Y. Naturally occurring TPE-CA maintains gut microbiota and bile acids homeostasis via FXR signaling modulation of the liver-gut axis. (2020) Frontiers in Pharmacology (IF=5.8), 11

38.Ni, S., Zhuo, Z., Pan, Y., Yu, Y., Li, F., Liu, J., Wang, L., Wu, X., Li, D., Wan, Y., Zhang, L., Yang, Z., Zhang, B.-T., Lu, A., Zhang, G. Recent Progress in Aptamer Discoveries and Modifications for Therapeutic Applications. (2020) ACS Applied Materials and Interfaces (IF=9.2)