灵芝是最著名的食用菌之一，被认为对长寿和活力非常有益。悠久的使用历史表明灵芝具有多种临床治疗作用。并且实验研究证实灵芝具有多种药理作用，包括抗肿瘤、抗菌、抗HIV蛋白酶、抗糖尿病活性等。随着研究的深入，已从灵芝中分离出300多个化合物。灵芝产品的数量不断增加，其国际化发展也在不断扩大。目前，灵芝的化学成分、治疗效果、临床价值和安全性备受关注。本文对这些方面进行了全面综述，以期加强灵芝的全球推广。

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Ganoderma lucidum, one of the most well-known edible fungi, is believed to be very beneficial for longevity and vitality. A long usage history suggests that G. lucidum has various clinical therapeutic effects. And experimental studies have confirmed that G. lucidum has multiple pharmacological effects, including antitumor, anti-microbial, anti-HIV protease, and antidiabetic activity and so on. With the deepening of research, more than 300 compounds have been isolated from G. lucidum. There is an increasing population of G. lucidum-based products, and its international development is expanding. Currently, G. lucidum has drawn much attention to its chemical composition, therapeutic effect, clinical value, and safety. This paper provides a comprehensive review of these aspects to enhance the global promotion of G. lucidum.