本研究采用静态平衡法结合高效液相色谱法研究姜黄素的溶解度。姜黄素在十二种纯溶剂（二甲亚砜、四氢呋喃、丙酮、乙酸乙酯、异丙醇、乙腈、1-丁醇、乙醇、甲醇、二甲苯、正己烷和正庚烷）和三种二元溶剂混合物（丙酮 + 四氢呋喃、乙腈 + 四氢呋喃和正己烷 + 四氢呋喃）在不同温度（T = 278.15-323.15 K）和大气压下。溶解度值表明在所有溶剂中溶解度都随着温度的升高而增加。修正的 Apelblat 模型和 Buchowski-Ksiazczak λh 模型用于拟合纯溶剂中的溶解度数据，结合近乎理想的二元溶剂/ Redlich-Kister (CNIBS/R-K) 模型和Jouyban-Acree 模型用于采用二元溶剂混合物中的溶解度数据。RAD最大改性Apelblat模型和λH模型的是2.621％和5.831％，则RMSD最大是6.9×10 -4和1.62×10 -3分别。CNIBS/R-K 模型和 Jouyban-Acree 模型的 RAD max为 2.249% 和 4.901%，RMSD max为 9.33×10 -3和 3.67×10 -3。同时，利用KAT-LSER模型探索姜黄素的溶剂化作用。所有方程的拟合结果证明了实验数据的准确性，这些溶解度数据对于优化姜黄素的提取工艺和重结晶非常重要。

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In the research, the solubility of curcumin was studied by static equilibrium method combined with HPLC. The solubility data of curcumin was measured in twelve pure solvents (dimethyl sulfoxide, tetrahydrofuran, acetone, ethyl acetate, isopropanol, acetonitrile, 1-butanol, ethanol, methanol, xylenes, n-hexane and n-heptane) and three binary solvent mixtures (acetone + tetrahydrofuran, acetonitrile + tetrahydrofuran and n-hexane + tetrahydrofuran) at different temperature (T=278.15- 323.15 K) under atmospheric pressure. The solubility values demonstrate that the solubility increased with the increase of temperature in all solvents. The modified Apelblat model and the Buchowski−Ksiazczak λh model were used to fitted the solubility data in pure solvents, the combined nearly ideal binary solvent/ Redlich-Kister (CNIBS/R−K) model and the Jouyban−Acree model were employed to adopt the solubility data in binary solvent mixtures. The RADmax of the modified Apelblat model and the λh model are 2.621% and 5.831%, the RMSDmax are 6.9×10-4 and 1.62×10-3, respectively. The RADmax of the CNIBS/R−K model and the Jouyban−Acree model are 2.249% and 4.901%, the RMSDmax are 9.33×10-3 and 3.67×10-3. Meanwhile, the KAT-LSER model was used to explore the effect of the solvation of curcumin. The fitting results of all equations prove the accuracy of the experimental data, these solubility data are very important for optimizing the extraction process and recrystallization of curcumin.