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11-羰基-Β-乙酰乳香酸性质、用途与生产工艺
概述
11- 羰基 -β- 乙酰乳香酸(Acetyl-11-keto-β-boswellic acid,AKBA) 能显著地抑制 5-脂氧合酶(5-LO)的形成,从而发挥强大的抗炎抗氧化作用,其次对肿瘤、溃疡和免疫调节等疾病表现出良好的治疗前景。AKBA 可以通过抑制 TNF-α 诱导的 NF-κB 活化,从而抑制基质金属蛋白酶的活化,起到血管保护作用;同类化合物甘草酸和积雪草酸被报道,基于其良好的抗氧化作用,可通过调节体内不同细胞因子表达,从而有效抑制和逆转血管重构。为西黄丸药制剂中重要活性成分。
![]() Human Endogenous Metabolite 体外研究 AKBA (Acetyl-11-keto-β-boswellic acid) significantly reduced infarct volumes and apoptotic cells, and also increased neurologic scores by elevating the Nrf2 and HO-1 expression in brain tissues in middle cerebral artery occlusion (MCAO) rats at 48 hours post reperfusion. In primary cultured neurons, AKBA increased the Nrf2 and HO-1 expression, which provided protection against OGD-induced oxidative insult. Additionally, AKBA treatment increased Nrf2 binding activity to antioxidant-response elements (ARE). AKBA (Acetyl-11-keto-β-boswellic acid) significantly inhibited human colon adenocarcinoma growth, showing arrest of the cell cycle in G1-phase and induction of apoptosis. AKBA (Acetyl-11-keto-β-boswellic acid) triggered significant lipolysis in 3T3-L1 adipocytes as shown by reduced neutral lipids in cytosol and increased free fatty acids in culture medium. Increased lipolysis by AKBA was accompanied by up-regulation of lipolytic enzymes, adipocyte triglyceride lipase (ATGL) and hormone sensitive lipase (HSL), and a decreased expression of lipid droplet stability regulator perilipin. In addition, AKBA (Acetyl-11-keto-β-boswellic acid) treatment reduced phenotypic markers of mature adipocyte aP2, adiponectin and glut-4 in mature adipocytes. 体内研究 AKBA (Acetyl-11-keto-β-boswellic acid) significantly prevented the formation of intestinal adenomatous polyps without toxicity to mice. AKBA's activity both in the prevention of small intestinal and colonic polyps was more potently than aspirin. Histopathologic examination revealed that AKBA's effect, that is the reduction of polyp size and degree of dysplasia, was more prominent in larger sized polyps, especially those originating in colon. AKBA (Acetyl-11-keto-β-boswellic acid) administration in mice effectively delayed the growth of HT-29 xenografts without signs of toxicity. The activity of AKBA was more potent than that of aspirin. AKBA (Acetyl-11-keto-β-boswellic acid) exhibited anti-cancer activity in vitro and in vivo. With oral application in mice, AKBA significantly inhibited SGC-7901 and MKN-45 xenografts without toxicity. 用途 用于含量测定/鉴定/药理实验等 11-羰基-Β-乙酰乳香酸 上下游产品信息 上游原料 下游产品 |
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