经皮给药是一种可行且经临床验证的给药途径。这条路线特别需要克服由表皮角质层以及真皮内的血管和神经网络提供的机械屏障。第一代透皮贴剂和第二代离子电渗贴剂已成功转化为商业临床产品。目前的审查报告了不同的研究，旨在增强使用微针的生物药物的透皮递送及其对药物递送的影响。微针 (MN) 是透皮贴剂和皮下注射器之间的微米级混合体。微针经过测试和证明可以更好地输送药物，克服了皮下注射器的缺点。已经制造了多种微针设计，即实心、涂层、空心和聚合物微针。空心微针长度较短，但与皮下注射针相似，并具有用于输注药物液体制剂的孔。实心微针在皮肤上开一个洞后贴上贴片；药物被涂在涂层微针的表面；聚合物微针可以是不同类型的，例如由聚合物组成的溶解性、非溶解性或水凝胶形成。讨论了与使用这些技术相关的各种优点和限制。与标准的注射给药途径相比，用微针递送肽和蛋白质分子代表了获得更好临床结果并因此创造价值的重要机会。目前，各种配方和微细加工技术的进步都集中在帮助通过微针递送蛋白质药物。讨论了微针介导的蛋白质和肽递送的最新进展和局限性。

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Transdermal drug delivery is a viable and clinically proven route of administration. This route specifically requires overcoming the mechanical barrier provided by the Stratum Corneum of epidermis and vascular and nervous networks within the dermis. First-generation Transdermal patches and second-generation iontophoretic patches have been translated into commercial clinical products successfully. The current review reports different studies that aim to enhance the transdermal delivery of biopharmaceutical using microneedles and their effect on drug delivery. Microneedles (MN) are the micron-scale hybrid between transdermal patches and hypodermic syringes. Microneedles are tested and proven to show better delivery of the drugs, overcoming the drawbacks of hypodermic syringes. Multiple microneedles designs have been fabricated i.e. solid, coated, hollow, and polymer microneedles. Hollow microneedles are shorter in length but similar to hypodermic needles and have pore for infusion of liquid formulation of the drug. Solid microneedles a patch is applied after creating a hole in the skin; Drugs are coated on the surface of Coated microneedles; Polymer microneedles can be of different types like dissolving, non-dissolving or hydrogel-forming made up of polymers. Various advantages and limitations associated with the use of these techniques are discussed. Delivery of peptide and protein molecules with microneedles represents a significant opportunity for a better clinical outcome and hence value creation compared to standard injectable routes of administration. The advancement in various formulation and microfabrication techniques are currently being focused to aid the delivery of protein drugs via microneedles. The most recent advances and limitations in Microneedles -mediated protein and peptide delivery were discussed.