You can refer to very dirty, unpleasant conditions as squalor.

【例句】

He was out of work and living in squalor.

Amid the filth（污物,污秽） and squalor, my parents taught me the values I live by.

Overnight, he wrote, he moved from the "safety and cleanliness of rural poverty" to the "foulest（最肮脏的） kind of urban squalor."（城市贫民区）

The medical team found 60,000 emaciated（瘦弱的） prisoners living in unimaginable squalor.

How can you live in such squalor?

Synonyms同义词: filth ;wretchedness ;sleaziness ;decay ;foulness ;slumminess ;squalidness ;meanness 

Opposites反义词：luxury , splendour , cleanliness , neatness , fine condition, pleasantness

1 (adjective)  in the sense of dirty作为形容词“肮脏的”意思

Definition——dirty, untidy, and in bad condition

中文意思可以是：肮脏的，邋遢的

The migrants have been living in squalid conditions.

Synonyms同义词：dirty ;filthy ;seedy ;sleazy ;sordid ;low ;nasty ;foul ;disgusting ;rundown ;decayed ;repulsive ;poverty-stricken ;unclean ;fetid ;slovenly ;skanky (slang) ;slummy ;yucky or yukky (slang) ;yucko (Australian, slang) ;festy (Australian, slang) 

Opposites反义词：clean , spotless , hygienic , attractive , pleasant , tidy , in good condition, well looked-after, salubrious , spick-and-span , well-kept

2 (adjective)  in the sense of unseemly作文形容词“不合适的，不得体的”意思

Definition——unpleasant, selfish, and often dishonest

中文意思可以是：道德败坏的;丑恶的;卑鄙的

the squalid pursuit of profit

Synonyms同义词：unseemly ;sordid ;inappropriate ;unsuitable ;out of place ;improper ;undignified ;disreputable ;unbecoming ;unrefined ;out of keeping ;discreditable ;indelicate ;in poor taste ;indecorous ;unbefitting

【例句】

He followed her up a rickety staircase to a squalid bedsit他跟着她上了一段摇摇晃晃的楼梯，来到了一间邋遢的卧室起居室两用房间。

The Tory Party called the bill 'the most squalid measure ever put before the Commons'.保守党称该议案为“有史以来向下议院提出的最卑鄙的议案”。

The migrants have been living in squalid conditions. 移民们的生活条件一直非常差。

They're involved in a rather squalid battle as to who controls the party.他们在由谁控制该党的问题上卷入了一场十分卑鄙的争斗。