microRNAs( miRNAs) are low-molecular-weight non-coding RNAs that regulate various physiological and pathological functions through the regulation of gene expression at the post-transcriptional level. More and more evidence has shown that microRNA-27 a( miRNA-27 a) plays a role in the development and pathogenesis of liver diseases. By reviewing and updating related studies,this article introduces the research advances in the role of miRNA-27 a in various liver diseases including fatty liver disease,hepatitis,hepatic fibrosis,and liver cancer and analyzes the role of miRNA-27 a in liver regeneration and its potential as a biomarker,so as to provide a reference for future studies and more possibilities for new treatment ideas for chronic hepatic diseases.