在组织界面处缺乏湿粘附力和生物力学失配是与外科手术粘合剂制剂有关的主要挑战。基于碳烯的生物粘合剂试图解决这些局限性，因为它们具有共价键结合到湿组织表面的能力。在此，报道了溶解在各种液体聚乙二醇（PEG）中的二嗪基接枝的聚酰胺基胺（PAMAM）树状聚合物（PDz）。用高分子量PEG（2 kDa，6 kDA和10 kDa）增强的非水液态PEG 400溶解了PDz，形成了三次共混物，以优化粘度和剪切储能模量。动态光流变法将PEG的摩尔质量和三级比与粘附强度，水溶胀曲线和水性介质中的潜在重量损失相关联。

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Lack of wet adhesion and biomechanical mismatch at tissue interfaces are the major challenges related to surgical adhesive formulations. Carbene-based bioadhesives seek to address those limitations, due to their ability to covalently bond to wet tissue surfaces. Herein, diazirine-grafted polyamidoamine (PAMAM) dendrimers (PDz) dissolved in various liquid polyethylene glycols (PEG) are reported. Non-aqueous liquid PEG 400 reinforced with high molecular weight PEGs (2 kDa, 6 kDA and 10 kDa) dissolved PDz to form tertiary blends for optimization of viscosity and shear storage modulus. Dynamic photorheometry correlated PEG molar mass and tertiary ratios to adhesion strength, swelling-in-water profile and potential weight loss in aqueous medium. Tertiary blended adhesives demonstrate an improvement in elongation and adhesion strength compared to the binary blends used as control.