CHMP5 属于染色质修饰蛋白/带电多泡体蛋白 (CHMP) 家族。这些蛋白质是 ESCRT-III (运输 III 所需的内体分选复合物) 的组分，ESCRT-III 是一种参与表面受体蛋白降解和内吞多泡体 (MVB) 形成的复合物。一些 CHMP 具有细胞核和细胞质/囊泡分布，其中一种 CHMP，CHMP1A (MIM 164010) ，是 MVB 形成和细胞周期进程调节所必需的 (Tsang 等人，2006 [PubMed 16730941]) 。[OMIM，2008 年 3 月]

CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface Receptor Proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]