|
ZFHX3 zinc finger homeobox 3Gene ID: 463, updated on
9-Jul-2023Gene type: protein codingAlso known as: ATBT; ATBF1; ZFH-3; ZNF927; C16orf47See all available tests in GTR for this geneGo to complete Gene record for ZFHX3Go to Variation Viewer for ZFHX3 variantsSummary This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] Associated conditionsSee all available tests in GTR for this gene DescriptionTestsA genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease.GeneReviews: Not availableA sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.GeneReviews: Not availableGenetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.GeneReviews: Not availableGenome-wide association analyses identify variants in developmental genes associated with hypospadias.GeneReviews: Not availableGenome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.GeneReviews: Not availableMalignant tumor of prostateMedGen: C0376358OMIM: 176807GeneReviews: Not availableSee labsMeta-analysis identifies six new susceptibility loci for atrial fibrillation.GeneReviews: Not availableNovel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.GeneReviews: Not availableVariants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.GeneReviews: Not availableGenomic contextLocation:16q22.2-q22.3Sequence: Chromosome: 16; NC_000016.10 (72782885..73891930, complement)Total number of exons:23Go to nucleotideGraphics FASTA GenBank VariationResourceLinks for this geneClinVarVariants reported to ClinVardbVarStudies and variantsSNPGeneView ReportGo to Variation Viewer for ZFHX3 variants1000 GenomesSee 1000 Genomes Browser (GRCh37.p13)Related articles in PubMedPubMed-OMIMpublications in PubMed explicitly cited by the gene record in OMIM.
PubMed Clinical Queriespublications in PubMed limited specific clinical
research.All related articles in PubMedsorted by relevance are shown below. Click to see all (119) citations.Influence of ZFHX3 Polymorphisms on the Risk of Ischemic Stroke in Chinese Han Population.Hu W, Wang G, Wang P, Jin H, Liu J, Dang XHu W, et al. Cardiovasc Toxicol, 2023 Feb. PMID 36800142ATBF1 is a potential diagnostic marker of histological grade and functions via WNT5A in breast cancer.Li M, Zheng Y, Li X, Shen X, Zhang T, Weng B, Mao H, Zhao JLi M, et al. BMC Cancer, 2022 Dec 7. PMID 36476423Association between the rs2106261 polymorphism in the zinc finger homeobox 3 gene and risk of atrial fibrillation: Evidence from a PRISMA-compliant meta-analysis.Wei Y, Wang L, Lin C, Xie Y, Bao Y, Luo Q, Zhang NWei Y, et al. Medicine (Baltimore), 2021 Dec 10. PMID 34889223ZFHX3 knockdown dysregulates mitochondrial adaptations to tachypacing in atrial myocytes through enhanced oxidative stress and calcium overload.Lkhagva B, Lin YK, Chen YC, Cheng WL, Higa S, Kao YH, Chen YJLkhagva B, et al. Acta Physiol (Oxf), 2021 Apr. PMID 33332716ATBF1 Participates in Dual Functions of TGF-尾 via Regulation of Gene Expression and Protein Translocalization.Li M, Zhang A, Zheng Y, Li J, Zhao JLi M, et al. Biomolecules, 2020 May 24. PMID 32456355
|