该基因编码丝裂原活化蛋白激酶激酶激酶 14，它是一种丝氨酸/苏氨酸蛋白激酶。这种激酶与 TRAF2 结合并刺激 NF-kappaB 活性。它与其他几种 MAPKK 激酶具有序列相似性。它参与了肿瘤坏死/神经生长因子 (TNF/NGF) 家族受体和白细胞介素 1 I 型受体共有的 NF-kappaB 诱导信号级联。[RefSeq 提供，2008 年 7 月]

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]