丝胶是一种粘性蛋白质物质，由蚕产生，用于紧紧抓住蚕丝。天然生丝的主要成分是丝胶和丝心蛋白。丝心蛋白和丝胶在增加强度、刚度和保持茧的结构完整性方面起着至关重要的作用。这篇综述报告了几种类型的脱胶剂在从丝绸表面去除丝胶中的作用，并概述了组织工程领域中的丝素蛋白方法。系统地分析和讨论了丝胶去除（脱胶）的主要因素。影响蚕丝表面改性的关键因素包括表面活性剂、脱胶时间、温度、超声波、微波辐射、红外辐射等先进技术，低温氧等离子体辐射和PH值。这些因素在脱胶过程中单独或累积影响。组织工程是一种通过采用使用大量生物材料、细胞和营养特异性生长因子实践的技术概念来恢复组织功能障碍的最有效和最乐观的方法。不同类型的材料包括各种生物材料，其主要成分是丝素蛋白，是组织工程应用中最乐观的生物材料。丝素蛋白是一种基于天然蛋白质的聚合物，具有显着的理化特性，具有出色的生物相容性、易于生物降解、适当的氧气和水蒸气渗透性以及最少的炎症反应。

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Sericin is a sticky protein substance, which is generated by the silk-worm for holding the filaments of silk tightly. The main constituent of natural crude silk is made up of sericin and fibroin. Fibroin and sericin play a vital role in increasing the strength, stiffness and on maintaining the constructional integrality of the cocoon. This review reports the role of several types of degumming agents for the removal of sericin from silk surfaces and an overview of silk fibroin approaches in the tissue engineering field. The prime factors responsible for the removal of sericin (degumming) from silk were systematically analyzed and discussed. The key factors affects on modification of the silk surface are includes surfactant, degumming time, temperature, advanced techniques such as ultra-sonication, microwave radiation, infrared radiation, low-temperature oxygen plasma radiation, and PH. These factors influence either individually or cumulatively at the degumming process. Tissue engineering is an emanate and most optimistic approach to restore tissue malfunction by adopting the concept of the technology being practiced using numerous biomaterials, cells, and the nutrient-specific growth factors. Different types of materials include various bio-material and mainly of silk fibroin constituent of it is conceding most optimistic biomaterials in tissue engineering application. Silk fibroin is a naturalistic protein-based polymer with an eminent physiochemical characteristic, are magnificent biocompatibility, amenable biodegradability, proper oxygen, and water-vapor permeability, and least inflammatory reaction. The critical studies accomplishing on the role of Silk fibroin and various approaches adopted in the degumming process is extensively reviewed and reported.